1030608-30-0Relevant articles and documents
Anticancer activities of some arylcarbamoylalkyltriphenylphosphonium chlorides
Zhaowen, Lou,Li, Zhou,Chunfen, Xiao,Yong, Ye,Fanbo, Zeng,Kaixun, Huang
, p. 380 - 391 (2008/12/21)
A series of novel arylcarbamoylalkyltriphenylphosphonium chlorides were synthesized. The newly synthesized compounds, [R-(p-C6H 4)-NH-CO-R1P⊕(C6H 4)3]Clθ, R = H (2), CH3 (4), NO2 (6), R1 = -CH2- (b), CH3CH2CH2- (c), -CH2CH2CH 2 (d), the analogs of an anticancer drug, were characterized by infrared (IR), 1H nuclear magnetic resonance (NMR), 13C-NMR, 31P-NMR, mass spectrometry (MS), thermogravimetry (TG), and conductivity measurements. The anticancer activities of the obtained compounds were measured by MTT. The preliminary results indicated that some compounds showed potent anticancer activities against HCT-8, Bel-7402, A549, and S180.