1030631-30-1

Basic information

• Product Name: C₂₂H₁₉ClN₄O₃S₂
• CAS NO: 1030631-30-1
• Molecular Weight: 487.003
• Mol File: 1030631-30-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₂H₁₉ClN₄O₃S₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₂H₁₉ClN₄O₃S₂(1030631-30-1)
• EPA Substance Registry System: C₂₂H₁₉ClN₄O₃S₂(1030631-30-1)

Safety Data

• Hazardous Substances Data: 1030631-30-1(Hazardous Substances Data)

Upstream product

• 67617-98-5 (2,5-dimethoxyphenyl)thiourea 

Relevant articles and documents

4′-Methyl-4,5′-bithiazole-based correctors of defective ΔF508-CFTR cellular processing

The synthesis and ΔF508-CFTR corrector activity of a 148-member methylbithiazole-based library are reported. Synthetic routes were devised and optimized to generate methylbithiazole analogs in four steps. Corrector potency and efficacy were assayed using epithelial cells expressing human ΔF508-CFTR. These structure-activity data establish that the bithiazole substructure plays a critical function; eight novel methylbithiazole correctors were identified with low micromolar potencies.