1030770-99-0Relevant articles and documents
A furanyl acryl conjugated coumarin as an efficient inhibitor and a highly selective off-on fluorescent probe for covalent labelling of thioredoxin reductase
Huang, Lei,Chen, Yu,Liang, Baoxia,Xing, Bengang,Wen, Gesi,Wang, Shuni,Yue, Xin,Zhu, Cuige,Du, Jun,Bu, Xianzhang
, p. 6987 - 6990 (2014)
A simple and novel furanyl acryl conjugated coumarin fluorophore was designed as an effective thioredoxin reductase (TrxR)-responding fluorescent probe by an activity-guided approach. Basically, the α,β-unsaturated ketone moiety in the probe structure could quench the fluorescence of the coumarin, but upon the covalent modification of TrxR, a significant fluorescence could be generated, which has been confirmed to be obviously selective over Trx, GSH, Cys and DTT. the Partner Organisations 2014.