1030846-75-3

Upstream product

• 691904-78-6 3-(2-fluoro-4-hydroxyphenyl)propanoic acid ethyl ester 
• 1030848-32-8 [1-(2-phenoxyethyl)-1,2,3,4-tetrahydroquinolin-5-yl]methanol 

Downstream Products

• 1030849-38-7 sodium 3-(2-fluoro-4-{[1-(2-phenoxyethyl)-1,2,3,4-tetrahydroquinolin-5-yl]methoxy}phenyl)propanoate 

Relevant academic research and scientific papers

CARBOXYLIC ACID DERIVATIVE

To provide a compound which is usable as a drug, in particular, an insulin secretagogue or a preventive or remedy for a disease in which GPR40 participates such as diabetes or the like. [MEANS FOR SOLVING PROBLEMS] If is found out that a novel carboxylic acid derivative, which is characterized in that a carboxylic acid is bonded via two atoms to a 6-membered monocyclic aromatic ring and this aromatic ring is further bonded via a linker to a nitrogen-containing bicyclic ring, or its salt has an excellent GPR40 agonist activity, Because of showing excellent effects of promoting insulin secretion and lowering blood glucose level, this carboxylic acid derivative is useful as an insulin secretagogue or a preventive or remedy for diabetes.