103085-54-7

Upstream product

• 103085-53-6 8-(1,2-dihydroxypropyl)-3-methyl-2-phenyl-4H-1-benzopyran-4-one 
• 3468-01-7 3-methylflavone-8-carboxylic acid 
• 51950-71-1 3-methyl-4-oxo-2-phenyl-4H-1-benzopyran-8-carbonyl chloride 
• 103085-50-3 8-(1,2-epoxypropyl)-3-methyl-2-phenyl-4H-1-benzopyran-4-one 

Downstream Products

• 110714-49-3 dimethyl 2,6-dimethyl-4-(3-methylflavon-8-yl)-1,4-dihydropyridine-3,5-dicarboxylate 
• 152737-41-2 8-methylaminomethyl-3-methyl-4-oxo-2-phenyl-4H-1-benzopyran 
• 3468-01-7 3-methylflavone-8-carboxylic acid 

Relevant academic research and scientific papers

Therapeutically active flavonyl-1,4-dihydrophyridines

The novel flavonyl-1,4-dihydropyridines having the general formula (I): STR1 are therapeutically effective calcium antagonists and smooth muscle relaxant.

Electrochemical Epoxidation and Carbon-Carbon Bond Cleavage for the Preparation of 3-Methyl-4-oxo-2-phenyl-4H-1-benzopyran-8-carboxylic Acid from 3-Methyl-2-phenyl-8-(1-propenyl)-4H-1-benzopyran-4-one

Electrooxidative carbon-carbon bond cleavage is useful for the preparation of 3-methyl-4-oxo-2-phenyl-4H-1-benzopyran-8-carboxylic acid (1b) from 3-methyl-2-phenyl-8-(1-propenyl)-4H-benzopyran-4-one (2).Olefin 2 was transformed into 3-methyl-8-(1,2-epoxypropyl)-3-methyl-2-phenyl-4H-1-benzopyran-4-one (3) by the electrochemical bromohydrination in an MeCN-H2O-H2SO4-NaBr-(Pt) system followed by treatment of aqueous sodium hydroxide (94percent).The epoxide 3 was electrooxidized in an MeOH-H2SO4-(C) system, affording 8-formyl-3-methyl-2-phenyl-4H-1-benzopyran-4-one (4) in 83percent yield.Hydrogen peroxide oxidation of 4 in refluxing 2-butanone gave 1b in 86percent yield.