1030852-48-2Relevant academic research and scientific papers
Convenient enantioselective synthesis of β-trifluoromethyl-β-aminoketones by organocatalytic asymmetric Mannich reaction of aryl trifluoromethyl ketimines with acetone
Sukach, Volodymyr A.,Golovach, Nataliya M.,Pirozhenko, Volodymyr V.,Rusanov, Eduard B.,Vovk, Mykhaylo V.
, p. 761 - 764 (2008)
The l-proline-catalyzed asymmetric Mannich reaction has been performed between aryl trifluoromethyl ketimines and acetone to provide, for the first time, chiral β-aryl-β-trifluoromethyl-β-aminoketones in high yields and with 74-92% enantiomeric excesses.
