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10310-21-1

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10310-21-1 Usage

Description

Different sources of media describe the Description of 10310-21-1 differently. You can refer to the following data:
1. 6-Chloroguanine, also be known as 2-Amino-6-chloropurine may be used in the enzymatic synthesis of 2′-deoxyguanosine, 9-alkyl purines (R)and (S)-N(2-phosphonomethoxypropyl) derivatives of purine and pyrimidine bases. It is also useful during the synthesis of guanine.
2. 2-Amino-6-chloropurine is a precursor in the synthesis of nucleoside analogs with antiviral activity against Epstein-Barr virus (EBV) and human herpes virus 6 (HHV-6).

Chemical Properties

white to light yellow crystal powder

Uses

Different sources of media describe the Uses of 10310-21-1 differently. You can refer to the following data:
1. 2-Amino-6-chloropurine may be used:in the enzymatic synthesis of 2′-deoxyguanosinein the synthesis of 9-alkyl purinesin the synthesis of (R)- and (S)-N-(2-phosphonomethoxypropyl) derivatives of purine and pyrimidine bases
2. 2-Amino-6-chloropurine finds its uses in the enzymatic synthesis of 2?-deoxyguanosine, 9-alkyl purines and (R)- and (S)-N-(2-phosphonomethoxypropyl) derivatives of purine and pyrimidine bases.

Definition

ChEBI: An organochlorine compound that is 7H-purin-2-amine substituted by a chloro group at position 6.

General Description

2-Amino-6-chloropurine is a 6-substituted purine. Tautomeric purine forms of 2-amino-6-chloropurine were investigated by vibrational spectroscopy and quantum chemical method.

Check Digit Verification of cas no

The CAS Registry Mumber 10310-21-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,3,1 and 0 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 10310-21:
(7*1)+(6*0)+(5*3)+(4*1)+(3*0)+(2*2)+(1*1)=31
31 % 10 = 1
So 10310-21-1 is a valid CAS Registry Number.
InChI:InChI=1/C5H4ClN5/c6-3-2-4(9-1-8-2)11-5(7)10-3/h1H,(H3,7,8,9,10,11)

10310-21-1 Well-known Company Product Price

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  • (Code)Product description
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  • Detail
  • TCI America

  • (A1407)  2-Amino-6-chloropurine  >98.0%(HPLC)(T)

  • 10310-21-1

  • 1g

  • 350.00CNY

  • Detail
  • TCI America

  • (A1407)  2-Amino-6-chloropurine  >98.0%(HPLC)(T)

  • 10310-21-1

  • 5g

  • 990.00CNY

  • Detail
  • Alfa Aesar

  • (A18195)  2-Amino-6-chloropurine, 99%   

  • 10310-21-1

  • 1g

  • 638.0CNY

  • Detail
  • Alfa Aesar

  • (A18195)  2-Amino-6-chloropurine, 99%   

  • 10310-21-1

  • 5g

  • 2102.0CNY

  • Detail
  • Alfa Aesar

  • (A18195)  2-Amino-6-chloropurine, 99%   

  • 10310-21-1

  • 25g

  • 7648.0CNY

  • Detail
  • Aldrich

  • (109789)  2-Amino-6-chloropurine  ≥99%

  • 10310-21-1

  • 109789-1G

  • 1,041.30CNY

  • Detail
  • Aldrich

  • (109789)  2-Amino-6-chloropurine  ≥99%

  • 10310-21-1

  • 109789-5G

  • 4,186.26CNY

  • Detail
  • Aldrich

  • (342300)  2-Amino-6-chloropurine  97%

  • 10310-21-1

  • 342300-1G

  • 492.57CNY

  • Detail
  • Aldrich

  • (342300)  2-Amino-6-chloropurine  97%

  • 10310-21-1

  • 342300-5G

  • 1,517.49CNY

  • Detail
  • USP

  • (1269141)  FamciclovirRelatedCompoundF  United States Pharmacopeia (USP) Reference Standard

  • 10310-21-1

  • 1269141-25MG

  • 13,501.80CNY

  • Detail

10310-21-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name 6-chloroguanine

1.2 Other means of identification

Product number -
Other names 2-Amino-6-chloropurine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:10310-21-1 SDS

10310-21-1Synthetic route

6-chloro-2-formylaminopurine acetate
190962-00-6

6-chloro-2-formylaminopurine acetate

2-Amino-6-chloropurin
10310-21-1

2-Amino-6-chloropurin

Conditions
ConditionsYield
With water; sodium hydroxide at 20℃; for 3h;89%
2,9-diacetylguanine
3056-33-5

2,9-diacetylguanine

2-Amino-6-chloropurin
10310-21-1

2-Amino-6-chloropurin

Conditions
ConditionsYield
With trichlorophosphate In 1,2-dichloro-ethane; PEG-2000 at 80℃; for 6.33333h;84%
C5H2ClN5O2

C5H2ClN5O2

2-Amino-6-chloropurin
10310-21-1

2-Amino-6-chloropurin

Conditions
ConditionsYield
With methanol; hydrazine hydrate at 50℃; Reagent/catalyst; Solvent; Reflux;81.6%
N-(6-chloro-9H-purin-2-yl)formamide
149948-30-1

N-(6-chloro-9H-purin-2-yl)formamide

2-Amino-6-chloropurin
10310-21-1

2-Amino-6-chloropurin

Conditions
ConditionsYield
With sodium hydroxide at 20 - 80℃; for 3h;80%
With water; sodium hydrogencarbonate at 25℃; for 3h; Reagent/catalyst;73.3%
2-phenylmethylamino-6-chloropurine

2-phenylmethylamino-6-chloropurine

2-Amino-6-chloropurin
10310-21-1

2-Amino-6-chloropurin

Conditions
ConditionsYield
75%
2-amino-1,9-dihydro-6H-purin-6-one
73-40-5

2-amino-1,9-dihydro-6H-purin-6-one

2-Amino-6-chloropurin
10310-21-1

2-Amino-6-chloropurin

Conditions
ConditionsYield
With trichlorophosphate In N,N-dimethyl-formamide at 0℃; for 6h; Reflux;70%
With trichlorophosphate In ammonium hydroxide; water; N,N-dimethyl-formamide55%
With tetraethylammonium chloride; trichlorophosphate In water; acetonitrile42%
methyltriethylammonium chloride (TEMAC)

methyltriethylammonium chloride (TEMAC)

2-amino-1,9-dihydro-6H-purin-6-one
73-40-5

2-amino-1,9-dihydro-6H-purin-6-one

pyrographite
7440-44-0

pyrographite

2-Amino-6-chloropurin
10310-21-1

2-Amino-6-chloropurin

Conditions
ConditionsYield
With trichlorophosphate In water; acetone; acetonitrile54%
ammonium sulfate

ammonium sulfate

2-amino-1,9-dihydro-6H-purin-6-one
73-40-5

2-amino-1,9-dihydro-6H-purin-6-one

2-Amino-6-chloropurin
10310-21-1

2-Amino-6-chloropurin

Conditions
ConditionsYield
With N-benzyl-N,N,N-triethylammonium chloride; 1,1,1,3,3,3-hexamethyl-disilazane; trichlorophosphate In N,N-dimethyl acetamide; acetonitrile
With potassium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; 1,1,1,3,3,3-hexamethyl-disilazane; trichlorophosphate In N,N-dimethyl acetamide; acetonitrile
N2,9-diacetylguanine

N2,9-diacetylguanine

2-Amino-6-chloropurin
10310-21-1

2-Amino-6-chloropurin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: trichlorophosphate
2: water; sodium hydroxide
View Scheme
2-acetamido-9-acetyl-6-chloropurine
97965-44-1

2-acetamido-9-acetyl-6-chloropurine

2-Amino-6-chloropurin
10310-21-1

2-Amino-6-chloropurin

Conditions
ConditionsYield
With water; sodium hydroxide
2-amino-6-hydroxypurine
73-40-5

2-amino-6-hydroxypurine

2-Amino-6-chloropurin
10310-21-1

2-Amino-6-chloropurin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: acetic acid
2: trichlorophosphate
3: water; sodium hydroxide
View Scheme
Multi-step reaction with 3 steps
1: dihydrogen peroxide / water / 2 h / 20 °C
2: thionyl chloride / methanol / 0.33 h / 0 - 5 °C / Reflux
3: methanol; hydrazine hydrate / 50 °C / Reflux
View Scheme
With hydrogenchloride; dihydrogen peroxide In water at 40 - 50℃; for 3h; Reagent/catalyst;95.6 g
C8H9ClN6
149948-29-8

C8H9ClN6

2-Amino-6-chloropurin
10310-21-1

2-Amino-6-chloropurin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: water / 4.5 h / 70 °C
2: water; sodium hydroxide / 3 h / 20 °C
View Scheme
(E)-N'-(6-chloro-9H-purin-2-yl)-N,N-dimethylformimidamide

(E)-N'-(6-chloro-9H-purin-2-yl)-N,N-dimethylformimidamide

2-Amino-6-chloropurin
10310-21-1

2-Amino-6-chloropurin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: water / 4 h / 70 °C
2: sodium hydroxide / 3 h / 20 - 80 °C
View Scheme
2-Amino-6-chloropurin
10310-21-1

2-Amino-6-chloropurin

trimethylamine
75-50-3

trimethylamine

2-amino-N,N,N-trimethyl-9H-purine-6-ylammonium chloride
34798-95-3

2-amino-N,N,N-trimethyl-9H-purine-6-ylammonium chloride

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 20℃; for 1h; Inert atmosphere;100%
In ethanol; dimethyl sulfoxide at 20℃; for 12h;76%
In dimethyl sulfoxide for 12h;72%
2-Amino-6-chloropurin
10310-21-1

2-Amino-6-chloropurin

9-acetyl-2-amino-6-chloro-9H-purine
470483-92-2

9-acetyl-2-amino-6-chloro-9H-purine

Conditions
ConditionsYield
With acetic anhydride; triethylamine In isopropyl alcohol; toluene100%
2-Amino-6-chloropurin
10310-21-1

2-Amino-6-chloropurin

1,2-di-O-acetyl-3-O-(3',4'-di-O-acetyl-2',6'-di-O-benzyl-α-D-glucopyranosyl)-5-O-benzyl-α/β-D-ribofuranoside
197644-83-0

1,2-di-O-acetyl-3-O-(3',4'-di-O-acetyl-2',6'-di-O-benzyl-α-D-glucopyranosyl)-5-O-benzyl-α/β-D-ribofuranoside

2-amino-6-chloro-9-[2'-O-acetyl-5'-O-benzyl-3'-O-(3'',4''-di-O-acetyl-2'',6''-di-O-benzyl-α-D-glucopyranosyl)-β-D-ribofuranosyl]purine
897364-66-8

2-amino-6-chloro-9-[2'-O-acetyl-5'-O-benzyl-3'-O-(3'',4''-di-O-acetyl-2'',6''-di-O-benzyl-α-D-glucopyranosyl)-β-D-ribofuranosyl]purine

Conditions
ConditionsYield
With trimethylsilyl trifluoromethanesulfonate In acetonitrile at 70℃;100%
Stage #1: 2-Amino-6-chloropurin; 1,2-di-O-acetyl-3-O-(3',4'-di-O-acetyl-2',6'-di-O-benzyl-α-D-glucopyranosyl)-5-O-benzyl-α/β-D-ribofuranoside In acetonitrile at 100℃; for 0.5h;
Stage #2: With trimethylsilyl trifluoromethanesulfonate In acetonitrile at 70℃; Vorbrueggen condensation; Further stages.;
90%
1-N-Boc-7-N(3-bromopropyl)-4-N,7-N-di(2-nosyl)-4-azeheptane-1,7-diamine
1380167-26-9

1-N-Boc-7-N(3-bromopropyl)-4-N,7-N-di(2-nosyl)-4-azeheptane-1,7-diamine

2-Amino-6-chloropurin
10310-21-1

2-Amino-6-chloropurin

C31H39ClN10O10S2

C31H39ClN10O10S2

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 60℃; for 108h; Inert atmosphere;100%
selenourea
630-10-4

selenourea

2-Amino-6-chloropurin
10310-21-1

2-Amino-6-chloropurin

6‑selenoguanine
5375-85-9

6‑selenoguanine

Conditions
ConditionsYield
In ethanol for 2h; Reflux; Inert atmosphere; Schlenk technique;100%
2-Amino-6-chloropurin
10310-21-1

2-Amino-6-chloropurin

3,4-difluoroaniline
3863-11-4

3,4-difluoroaniline

N6-(3,4-difluorophenyl)-9H-purine-2,6-diamine

N6-(3,4-difluorophenyl)-9H-purine-2,6-diamine

Conditions
ConditionsYield
at 130℃; for 0.0833333h; Irradiation;100%
sodium ethanolate
141-52-6

sodium ethanolate

2-Amino-6-chloropurin
10310-21-1

2-Amino-6-chloropurin

NU2046
51866-19-4

NU2046

Conditions
ConditionsYield
In 1-methyl-pyrrolidin-2-one at 100℃; for 0.05h; microwave irradiation;98%
di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

2-Amino-6-chloropurin
10310-21-1

2-Amino-6-chloropurin

tert-butyl 2-[bis(tert-butoxycarbonyl)amino]-6-chloro-9H-purine-9-carboxylate
309947-85-1

tert-butyl 2-[bis(tert-butoxycarbonyl)amino]-6-chloro-9H-purine-9-carboxylate

Conditions
ConditionsYield
With dmap In tetrahydrofuran at 20℃; for 18h; Acylation;97%
With dmap
With dmap
dimethyl amine
124-40-3

dimethyl amine

2-Amino-6-chloropurin
10310-21-1

2-Amino-6-chloropurin

N6,N6-dimethyl-9H-purine-2,6-diamine
5437-49-0

N6,N6-dimethyl-9H-purine-2,6-diamine

Conditions
ConditionsYield
In ethanol at 110℃; for 16h;97%
In N,N-dimethyl-formamide at 180℃; Microwave irradiation; Inert atmosphere;39%
at 95℃; for 2h;
2-Amino-6-chloropurin
10310-21-1

2-Amino-6-chloropurin

glycine
56-40-6

glycine

2-[(2-amino-9H-purin-6-yl)amino]acetic acid

2-[(2-amino-9H-purin-6-yl)amino]acetic acid

Conditions
ConditionsYield
With sodium carbonate In water for 8h; Reflux;97%
1,4-diaza-bicyclo[2.2.2]octane
280-57-9

1,4-diaza-bicyclo[2.2.2]octane

2-Amino-6-chloropurin
10310-21-1

2-Amino-6-chloropurin

1-(2-amino-9H-purin-6-yl)-4-aza-1-azoniabicyclo[2.2.2]octane chloride

1-(2-amino-9H-purin-6-yl)-4-aza-1-azoniabicyclo[2.2.2]octane chloride

Conditions
ConditionsYield
In dimethyl sulfoxide at 25℃; for 24h;96%
In dimethyl sulfoxide for 12h; Ambient temperature;90%
In N,N-dimethyl-formamide90%
With dimethyl sulfoxide In N,N-dimethyl-formamide87%
In dimethyl sulfoxide for 3h;
2-Amino-6-chloropurin
10310-21-1

2-Amino-6-chloropurin

benzylamine
100-46-9

benzylamine

2-amino-6-benzylaminopurine
4014-90-8

2-amino-6-benzylaminopurine

Conditions
ConditionsYield
With triethylamine In butan-1-ol at 110℃; for 3h;96%
at 110℃; for 0.25h; microwave irradiation;93%
In butan-1-ol at 110℃; for 3h;51%
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 0 - 90℃;
sodium phenoxide
139-02-6

sodium phenoxide

2-Amino-6-chloropurin
10310-21-1

2-Amino-6-chloropurin

2-amino-6-(phenyloxy)purine

2-amino-6-(phenyloxy)purine

Conditions
ConditionsYield
In dimethyl sulfoxide at 150℃; for 0.166667h; microwave irradiation;96%
aniline
62-53-3

aniline

2-Amino-6-chloropurin
10310-21-1

2-Amino-6-chloropurin

N6-phenyl-9H-purine-2,6-diamine
14051-72-0

N6-phenyl-9H-purine-2,6-diamine

Conditions
ConditionsYield
at 130℃; for 0.0833333h; microwave irradiation;96%
With triethylamine In N,N-dimethyl-formamide at 130℃; for 6h; Inert atmosphere;75%
With triethylamine In N,N-dimethyl-formamide at 90℃; for 0.3h; Inert atmosphere; Microwave irradiation;
2-(2-Bromo-2-nitro-propoxy)-tetrahydro-pyran
109178-34-9

2-(2-Bromo-2-nitro-propoxy)-tetrahydro-pyran

2-Amino-6-chloropurin
10310-21-1

2-Amino-6-chloropurin

2-amino-6-chloro-9-<1-nitro-1-<(tetrahydropyran-2-yloxy)methyl>ethyl>-9H-purine
911798-67-9

2-amino-6-chloro-9-<1-nitro-1-<(tetrahydropyran-2-yloxy)methyl>ethyl>-9H-purine

Conditions
ConditionsYield
With potassium carbonate In dimethyl sulfoxide; acetonitrile for 1.75h; Irradiation;95%
2-Amino-6-chloropurin
10310-21-1

2-Amino-6-chloropurin

ethyl 2-(N-(2-((tert-butoxycarbonyl)amino)ethyl)-2-chloroacetamido)acetate
169566-58-9

ethyl 2-(N-(2-((tert-butoxycarbonyl)amino)ethyl)-2-chloroacetamido)acetate

[[2-(2-Amino-6-chloro-purin-9-yl)-acetyl]-(2-tert-butoxycarbonylamino-ethyl)-amino]-acetic acid ethyl ester
169566-61-4

[[2-(2-Amino-6-chloro-purin-9-yl)-acetyl]-(2-tert-butoxycarbonylamino-ethyl)-amino]-acetic acid ethyl ester

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide for 4h; Ambient temperature;95%
cyclohex-3-enylmethanol
72581-32-9, 1679-51-2

cyclohex-3-enylmethanol

2-Amino-6-chloropurin
10310-21-1

2-Amino-6-chloropurin

NU2073

NU2073

Conditions
ConditionsYield
Stage #1: cyclohex-3-enylmethanol With sodium hydride In tetrahydrofuran for 0.5h; deprotonation;
Stage #2: 2-Amino-6-chloropurin In tetrahydrofuran Etherification; Heating; Further stages.;
95%
2,6-di-(pyrazol-1-yl)-4-(bromomethyl)pyridine
924633-25-0

2,6-di-(pyrazol-1-yl)-4-(bromomethyl)pyridine

2-Amino-6-chloropurin
10310-21-1

2-Amino-6-chloropurin

6-chloro-9-[2,6-di(pyrazol-1-yl)pyridin-4-yl]-methyl-9H-purin-2-ylamine
924633-27-2

6-chloro-9-[2,6-di(pyrazol-1-yl)pyridin-4-yl]-methyl-9H-purin-2-ylamine

Conditions
ConditionsYield
With sodium hydride; potassium iodide In N,N-dimethyl-formamide at 50℃; for 5h;95%
2-Amino-6-chloropurin
10310-21-1

2-Amino-6-chloropurin

methylhydrazine
60-34-4

methylhydrazine

6-(1-methylhydrazino)-9H-purin-2-amine

6-(1-methylhydrazino)-9H-purin-2-amine

Conditions
ConditionsYield
95%
2-Amino-6-chloropurin
10310-21-1

2-Amino-6-chloropurin

tert-butyl N-[cyclohexyl(p-tolylsulfonyl)methyl]carbamate
365441-86-7

tert-butyl N-[cyclohexyl(p-tolylsulfonyl)methyl]carbamate

tert-butyl (2-amino-6-chloro-9H-purin-9-yl)(cyclohexyl)methylcarbamate
1389318-44-8

tert-butyl (2-amino-6-chloro-9H-purin-9-yl)(cyclohexyl)methylcarbamate

Conditions
ConditionsYield
With sodium carbonate In water at 20℃; for 12h;95%
2-Amino-6-chloropurin
10310-21-1

2-Amino-6-chloropurin

(3aS,4S,6aR)-2,2-dimethyl-6-((trityloxy)methyl)-4,6a-dihydro-3aH-cyclopenta[d][1,3]dioxol-4-ol
163226-45-7

(3aS,4S,6aR)-2,2-dimethyl-6-((trityloxy)methyl)-4,6a-dihydro-3aH-cyclopenta[d][1,3]dioxol-4-ol

6-chloro-9-((3aS,4R,6aR)-2,2-dimethyl-6-((trityloxy)methyl)-4,6a-dihydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)-9H-purin-2-amine
1449328-92-0

6-chloro-9-((3aS,4R,6aR)-2,2-dimethyl-6-((trityloxy)methyl)-4,6a-dihydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)-9H-purin-2-amine

Conditions
ConditionsYield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 50℃; for 18h; Mitsunobu Displacement; Inert atmosphere;95%

10310-21-1Related news

Equilibrium solubility determination, modelling and thermodynamic aspects of 6-Chloroguanine (cas 10310-21-1) in aqueous co-solvent mixtures of N,N-dimethylformamide, isopropanol, 1,4-dioxane and dimethyl sulfoxide07/28/2019

The equilibrium solubility of 6-chloroguanine in four co-solvent mixtures of dimethyl sulfoxide (DMSO) (1) + water (2), N,N-dimethylformamide (DMF) + water (2), isopropanol (1) + water (2) and 1,4-dioxane (1) + water (2) over the temperature range from (278.15 to 333.15) K were reported. At the ...detailed

10310-21-1Relevant articles and documents

-

Balsinger,Montgomery

, p. 1573 (1960)

-

A new method to synthesize famciclovir

Luo, Lei,Chen, Guorong,Li, Yuanchao

, p. 2803 - 2808 (2008)

A new and efficient method has been reported for the synthesis of 2-amino-9-[4-acetoxy-3-(acetoxymethyl)butyl-1-yl]purine(famciclovir)starting from guanine. The route involves chlorination of guanine, optimized Mitsunobu reaction, coupling with diethyl malonate, hydrogenation, reduction and esterification,and the overall yield is about 29%. This method does not require any form of chromatographic purification to give pure famciclovir, and it is an industrially viable manufacturing process for this drug. The Japan Institute of Heterocyclic Chemistry.

Preparation method of purine nucleotide intermediate

-

Paragraph 0028-0032; 0037-0041; 0046-0050, (2021/06/21)

The invention relates to the technical field of medical intermediates, particularly to a preparation method of a purine nucleotide intermediate. The synthesis route of the preparation method comprises steps as follows: 1) carrying out a chlorination reaction on a raw material compound V and a thionyl chloride/hydrogen peroxide reaction system to obtain a compound IV; 2) reacting the compound IV with methylamine to obtain a compound III; and 3) reacting the compound III with a compound II in the presence of a catalyst to obtain a compound I. According to the invention, the synthetic route of the purine nucleotide intermediate is improved, the methylation is firstly carried out, and then the deprotection is carried out, so that the reaction condition is mild, the operation is simple, the yield and the purity are higher, and the method is suitable for industrial large-scale production.

Synthetic method 2 -amino -6 - chloropurine

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Paragraph 0048-0075, (2021/08/25)

The invention provides a synthetic method of 2 - amino -6 - chloropurine, and belongs to the field of organic synthesis. The synthesis method provided by the invention comprises the following steps: adding 2 -acetyl-6-hydroxypurine into the reaction container. The product and comprises hexachloroacetone, organic base A chloride, heating reflux reaction 2h - 48h, distillation to remove dimethyl sulfoxide, adding alkali liquor pH, reacting 1h - 12h, adjusting 7.0 - 7.5 to 2 - and separating and purifying to obtain the amino -6 - chloropurine of the target product. The nitrogen-containing phosphorus-containing reagent is greatly reduced, the emission of nitrogen-containing phosphorus-containing wastewater is reduced correspondingly, and large-scale process production is facilitated.

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