1031082-34-4Relevant academic research and scientific papers
Trifluoromethoxyl substituted phenylethylene diamines as high affinity σ receptor ligands with potent anti-cocaine actions
Smith, Trudy A.,Yang, Xiaowen,Wu, Huifang,Pouw, Buddy,Matsumoto, Rae R.,Coop, Andrew
experimental part, p. 3322 - 3325 (2009/04/05)
The phenylethylene diamines are a class of σ receptor ligands with excellent selectivity over other biological systems and with anti-cocaine actions that involve antagonism of σ1 receptors. In order to increase the potency of the aromatic methoxyl substituted analogues, trifluoromethoxyl groups were introduced to prevent metabolic demethylation. The para-substituted trifluoromethoxyl substituted analogues were shown to have increased σ receptor affinity and represent the most potent anti-cocaine phenylethylene diamines yet described.
