103112-36-3

Usage

Uses

Used in Agricultural Industry:
FENCHLORAZOL-ETHYL PESTANAL 250 MG is used as a pesticide and fungicide for protecting crops such as fruits, vegetables, and ornamental plants from insect and fungal damage. Its application helps in maintaining crop health and productivity by reducing losses caused by pests and diseases.
This chemical is employed for its ability to control a wide range of pests and fungal diseases, ensuring the protection and preservation of agricultural produce. However, it is crucial to adhere to safety guidelines and use this chemical with caution to minimize potential risks to human health and the environment.

InChI:InChI=1/C10H4Cl5N3O2/c11-4-1-2-6(5(12)3-4)18-9(10(13,14)15)16-7(17-18)8(19)20/h1-3H,(H,19,20)

Upstream product

• 103112-35-2 ethyl 1-(2,4-dichloro-phenyl)-5trichloromethyl-1H-[1,2,4]triazole-3-carboxylate 

Relevant academic research and scientific papers

Design, synthesis and evaluation of novel trichloromethyl dichlorophenyl triazole derivatives as potential safener

The dominance of safener can unite with herbicides acquiring the efficient protection of crop and qualifying control of weeds in agricultural fields. In order to solve the crop toxicity problem and exploit the novel potential safener for fenoxaprop-P-ethyl herbicide, a series of trichloromethyl dichlorobenzene triazole derivatives were designed and synthesized by the principle of active subunit combination. A total of 21 novel substituted trichloromethyl dichlorobenzene triazole compounds were synthesized by substituted aminophenol and amino alcohol derivatives as the starting materials, using cyclization and acylation. All the compounds were unambiguously characterized by IR,1H-NMR,13C-NMR, and HRMS. A greenhouse bioassay indicated that most of the title compounds could protect wheat from injury caused by fenoxaprop-P-ethyl at varying degrees, in which compound 5o exhibited excellent safener activity at a concentration of 10 μmol/L and was superior to the commercialized compound fenchlorazole. A structure–activity relationship for the novel compounds was determined, which demonstrated that those compounds containing benzoxazine groups showed better activity than that of oxazole-substituted compounds. Introducing a benzoxazine fragment and electron-donating group to specific positions could improve or maintain the safener activity for wheat against attack by the herbicide fenoxaprop-P-ethyl. A molecular docking model suggested that a potential mechanism between 5o and fenoxaprop-P-ethyl is associated with the detoxication of the herbicide. Results from the present work revealed that compound 5o exhibited good crop safener activities toward wheat and could be a promising candidate structure for further research on wheat protection.

Synthesis, Crystal Structure, and Safener Activity of N-1-(2,4-Dichlorophenyl)-5-(trichloromethyl)-1H-1,2,4-triazole-3-carbonylindoline

A new indoline derivative, N-1-(2,4-dichlorophenyl)-5-(trichloromethyl)-1H-1,2,4-triazole-3-carbonylindoline (C18H11Cl5N4O, Mr= 476.56), was designed and synthesized by a reaction containing hydrolysis and acylation using ethyl 1-(2,4-dichlorophenyl)-5-(trichloromethyl)-1H-1,2,4-triazole-3-carboxylate and indoline as the starting materials. The final product was characterized by IR, 1H-NMR, 13C-NMR, and HRMS. The single-crystal structure was confirmed by X-ray diffraction. The target compound was crystallized in monoclinic system, space group P 21/c with a = 11.5318(5) ?, b = 14.6054(7) ?, c = 12.6970(6) ?, β = 110.886(2)°, Z = 2, V = 1997.99(16) ?3, F(000) = 960, ￡>=1.584 Mg/m3, crystal size: 0.170 x 0.140 *0.120 mm. The analog physical and chemical properties between fenchlorazole-ethyl and the title compound provided a basis for splendid safener activity by molecular structure comparison. The bioassay indicated that the target compound manifested an outstanding efficacy on protecting wheat from herbicide fenoxaprop-p-ethyl.