1031291-58-3Relevant academic research and scientific papers
Highly Selective Synthesis of α-Aminoamide Utilizing an Umpolung Reaction and Characteristics of α-Hydrazonoester
Mizota, Isao,Mizukoshi, Nanami,Mizutani, Shunsuke,Nakamura, Yusuke,Shimizu, Makoto,Terasawa, Shunya
, p. 4168 - 4172 (2021)
An umpolung reaction with α-hydrazonoesters was investigated, and it was found that α-N,N-dialkylaminoamides could be directly synthesized in yields up to 92% via a concomitant rearrangement of dialkylamino groups. As an application, a short synthesis of an inhibitor of glycine type-1-transporter was accomplished via subsequent functional group transformations in 28% overall yield.
HETEROARYL AMIDES AS TYPE I GLYCINE TRANSPORT INHIBITORS
-
Page/Page column 79, (2008/12/06)
The present invention relates to a series of substituted heteroaryl amides of the Formula I, wherein HET, A, X1 -X4, and R1-R12 groups are defined as in the specification, that exhibit activity as glycine transport inhibitors, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and their use for the enhancement of cognition and the treatment of the positive and negative symptoms of schizophrenia and other psychoses in mammals, including humans.
