103147-22-4Relevant academic research and scientific papers
Polarization effect in luminescent mesogenic BF2 complexes derived from heterocyclic benzothiazoles
Hsu, Yuan?Chun,Wang, Chun?Yang,Hsiao, Pei?Chi,Cai, Yi-Hong,Lee, Gene?Hsiang,Lai, Chung K.
, (2019/12/09)
Two series of benzo(thia)xazoles 1–2 and one series of boron difluoride complexes 2-BF2 derived from benzothiazoles 2 were reported, and their mesomorphic and optical properties were investigated. The crystal and molecular structures of compound 2 and 2-BF2 (all n = 8) were determined by means of X?ray structural analysis, and both crystallize in the triclinic P-1 and monoclinic P21/c. The geometry at boron center is perfectly tetrahedral, and the overall molecular shapes are considered as rod?shape. Both benzo(thia)xazoles 1 and 2 exhibited N or/and SmC phase, and boron complexes 2-BF2 formed N or/and SmC phase. Benzothiazoles 2 showed a much wider temperature range of mesophase than those of benzoxazoles 1, which were attributed to the better polarization by sulfur atom incorporated. Boron complexes 2-BF2 (n = 10, 12) emitted a yellow?to?green emission at λmax = 569–571 nm in CH2Cl2. This is the first mesogenic BF2 complexes derived from benzothiazoles.
Discotic liquid crystals of transition metal complexes 45?: Parity effect of the number of d-electrons on stacking distances in the columnar mesophases of octakis-(M-alkoxyphenoxy)phthalocyaninato metal(II) complexes
Sato, Hiroyuki,Igarashi, Kensaku,Yama, Yoshitaka,Ichihara, Masahiro,Itoh, Eiji,Ohta, Kazuchika
, p. 1148 - 1158 (2013/01/15)
We have synthesized 34 novel homologous discotic liquid crystals, octakis(m-alkoxyphenoxy)phthalocyaninato metal(II) {abbreviated as (m-C nOPhO)8PcM (M = Co(1), Ni(2), Cu(3), Zn(4) and H 2(5); n = 8(a), 10(b), 12(c), 14(d)
Columnar/smectic metallomesogens derived from heterocyclic benzoxazoles
Wu, I-Tzu,Chaing, Pei-Yi,Chang, Wen-Jung,Sheu, Hwo-Shuenn,Lee, Gene-Hsiang,Lai, Chung K.
scheme or table, p. 7358 - 7369 (2011/10/12)
The synthesis, mesomorphic behavior, and optical properties of two new series of metal complexes 1a,b-M (M=Pd, Cu, Zn) derived from benzoxazoles 2a,b are reported. The crystal and molecular structures of mesogenic 5-decyloxy-2-(6-decyloxybenzooxazol-2-yl)
A novel class of potent nonglycosidic and nonpeptidic pan-selectin inhibitors
Ulbrich, Holger K.,Luxenburger, Andreas,Prech, Philip,Eriksson, Einar E.,Soehnlein, Oliver,Rotzius, Pierre,Lindbom, Lennart,Dannhardt, Gerd
, p. 5988 - 5999 (2007/10/03)
An early step of the inflammatory response, the rolling of leukocytes on activated endothelial cells, is mediated by selectin/carbohydrate interactions. The tetrasaccharide sialy LewisX is a ligand for E-, P-, and L-selectin and therefore serve
Design and synthesis of a novel and potent series of inhibitors of cytosolic phospholipase A2 based on a 1,3-disubstituted propan-2-one skeleton
Connolly, Stephen,Bennion, Colin,Botterell, Sarah,Croshaw, Pamela J.,Hallam, Catherine,Hardy, Kim,Hartopp, Paul,Jackson, Clive G.,King, Sarah J.,Lawrence, Louise,Mete, Antonio,Murray, David,Robinson, David H.,Smith, Gillian M.,Stein, Linda,Walters, Iain,Wells, Edward,Withnall, W. John
, p. 1348 - 1362 (2007/10/03)
Using knowledge of the substrate specificity of cPLA2 (phospholipases A2), a novel series of inhibitors of this enzyme were designed based upon a three point model of inhibitor binding to the enzyme active site comprising a lipophilic anchor, an electrophilic serine "trap", and an acidic binding moiety. The resulting 1,3-diheteroatom-substituted propan-2-ones were evaluated as inhibitors of cPLA2 in both aggregated bilayer and soluble substrate assays. Systematic variation of the lipophilic, electrophilic, and acidic groups revealed a well-defined structure-activity relationship against the enzyme. Optimization of each group led to compound 22 (AR-C70484XX), which contains a decyloxy lipophilic side chain, a 1,3-diaryloxypropan-2-one moiety as a unique serine trap, and a benzoic acid as the acidic binding group. AR-C70484XX was found to be among the most potent in vitro inhibitors of cPLA2 described to date being more than 20-fold more active against the isolated enzyme (IC50 = 0.03 μM) than the standard cPLA2 inhibitor, arachidonyl trifluoromethyl ketone (AACOCF3), and also greater than 10-fold more active than AACOCF3 against the cellular production of arachidonic acid by HL60 cells (IC50 = 2.8 μM).
