103166-35-4

Upstream product

• 1310823-53-0 (Z)-1,3,4,5-tetraphenylpent-4-en-1-one 
• 108-86-1 bromobenzene 
• 591-50-4 iodobenzene 
• 614-47-1 1,3-diphenyl-propen-3-one 
• 501-65-5 diphenyl acetylene 
• 4441-01-4 1,2,4-triphenylbutane-1,4-dione 
• 106-49-0 p-toluidine 
• 1240039-08-0 C₂₂H₁₆I₂ 

Downstream Products

• 1666-86-0 2,4,6-triphenylpyrimidine 

Relevant academic research and scientific papers

Synthesis of Tetrasubstituted Pyrroles from Homopropargylic Amines via a Sonogashira Coupling/Intramolecular Hydroamination/Oxidation Sequence

A one-pot reaction of homopropargylic amines and aryl iodides was developed in the presence of a palladium (Pd) catalyst and generated a series of tetrasubstituted pyrrole derivatives in good to high yields. This process involved a Sonogashira, intramolecular hydroamination, cyclization and oxidation sequence of reactions.

Enone-alkyne reductive coupling: A versatile entry to substituted pyrroles

The reductive coupling of enones or enals with alkynes, followed by olefin oxidative cleavage and Paal-Knorr cyclization, provides a versatile entry to a variety of pyrrole frameworks. A number of limitations of alternate entries to the requisite 1,4-dica

Copper-catalyzed double N-vinylation of aromatic amines: An efficient synthesis of various substituted N-arylpyrroies

A simple and efficient approach to various substituted N-arylpyrroles has been developed. The method is based on the copper-catalyzed sequential inter- and intramolecular Nvinylation of aromatic amines. The reactions proceed to afford substituted N-arylpyrroles in good-to-excellent yields using CuI as the precatalyst, iBuONa as the base, and N1,N2dimethylethane- l,2-diamine (DMEDA) as the ligand. Ani-lines with electron-donating and -withdrawing substituents as well as a heteroaromatic amine performed very well under the conditions used. Tri- and tetrasubstituted dienyl diiodides also performed well under the reaction conditions and afforded the corresponding substituted N-arylpyrroles in good yields, Products were also obtained in high yields with CuBr or CuCl as precatalyst.