103168-78-1

Basic information

• Product Name: 10-[2-(4-benzylpiperazin-1-yl)ethyl]-10H-phenothiazine
• CAS NO: 103168-78-1
• Molecular Formula: C₂₅H₂₇N₃S
• Molecular Weight: 401.567
• Mol File: 103168-78-1.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 559.1°C at 760 mmHg
• Flash Point: 291.9°C
• Density: 1.191g/cm³
• Vapor Pressure: 1.57E-12mmHg at 25°C
• Refractive Index: 1.65
• CAS DataBase Reference: 10-[2-(4-benzylpiperazin-1-yl)ethyl]-10H-phenothiazine(CAS DataBase Reference)
• NIST Chemistry Reference: 10-[2-(4-benzylpiperazin-1-yl)ethyl]-10H-phenothiazine(103168-78-1)
• EPA Substance Registry System: 10-[2-(4-benzylpiperazin-1-yl)ethyl]-10H-phenothiazine(103168-78-1)

Safety Data

• Hazardous Substances Data: 103168-78-1(Hazardous Substances Data)

Usage

Chemical class

Phenothiazine derivative

Use

Psychiatric medication and potent neuroleptic

Treatment

Schizophrenia and other psychotic disorders

Mechanism of action

Blocks dopamine and serotonin receptors in the brain

Antipsychotic effects

Resulting from receptor blocking

Sedative properties

Known for its calming effects

Antiemetic properties

Used to manage severe nausea and vomiting

Potential anti-cancer properties

Studied but requires further research for efficacy and safety

Structure

10-[2-(4-benzylpiperazin-1-yl)ethyl]-10H-phenothiazine

Upstream product

• 92-84-2 10H-phenothiazine 

Relevant articles and documents

Phenothiazine compound as well as preparation method and application thereof

The invention discloses a phenothiazine compound which has the advantages of novel structural general formula and framework, high efficiency, low toxicity and better inhibitory activity on LSD1. The invention also discloses a preparation method of the compound. The preparation method has the characteristics of mild reaction conditions, simplicity in operation and high reaction yield. According to the invention, phenothiazine is taken as a raw material, active groups are respectively introduced to a parent of phenothiazine, and new phenothiazine pharmacophores are synthesized; and phenothiazine compounds are designed and synthesized by modification with piperazine, morpholine, piperidine and other groups. The compound retains the activity of phenothiazine and also has the characteristics of modification groups, so that the biological activity of original molecules is improved, and the anti-tumor activity of target molecules is improved. The invention also discloses an application of the compound in preparation of LSD1-targeted antitumor drugs, and the compound shows good inhibitory activity on LSD1 and shows good development potential.