1031685-35-4Relevant articles and documents
An improved synthesis of (3R)-2-(tert-Butoxycarbonyl)-7-hydroxy-1,2,3,4- tetrahydroisoquinoline-3-carboxylic acid
Liu, Cong,Thomas, James B.,Brieaddy, Larry,Berrang, Bertold,Carroll, F. Ivy
, p. 856 - 858 (2008)
An improved synthesis of (3R)-2-(tert-butoxycarbonyl)-7-hydroxy-1,2,3,4- tetrahydroisoquinoline-3-carboxylic acid is described wherein a modified Pictet-Spengler reaction was employed to provide 95% yield of the product with 7% racemization or less. The enantiomeric excess of the final product was improved to 99.4% via recrystallization. The overall yield of this four-step synthesis provides the title compound in 43% starting from D-tyrosine. Georg Thieme Verlag Stuttgart.