1031704-72-9Relevant academic research and scientific papers
Solid-phase assembly and in situ screening of protein tyrosine phosphatase inhibitors
Srinivasan, Rajavel,Lay, Pheng Tan,Wu, Hao,Yao, Shao Q.
, p. 2295 - 2298 (2008)
(Chemical Equation Presented) A highly efficient solid-phase strategy for assembly of small molecule inhibitors against protein tyrosine phosphatase 1B (PTP1B) is described. The method is highlighted by its simplicity and product purity. A 70-member combinatorial library of analogues of a known PTP1B inhibitor has been synthesized, which upon direct in situ screening revealed a potent inhibitor (Ki = 7.0 μM) against PTP1B.
