1031749-07-1Relevant articles and documents
A facile and efficient multi-gram synthesis of N-protected 5-(guanidinocarbonyl)-1H-pyrrole-2-carboxylic acids
Schmuck, Carsten,Bickert, Volker,Merschky, Michael,Geiger, Lars,Rupprecht, Daniel,Dudaczek, Juergen,Wich, Peter,Rehm, Thomas,Machon, Uwe
, p. 324 - 329 (2008)
The synthesis of two versatile building blocks for supramolecular anion binding motifs, 5-(N-Boc-guanidinocarbonyl)-1H-pyrrole-2-carboxylic acid (1) and 5-(N-Cbz-guanidinocarbonyl)-1H-pyrrole-2-carboxylic acid (2) is reported. Using these building blocks, a guanidiniocarbonyl-pyrrole anion binding site can easily be introduced into more complex molecules by using standard amide coupling conditions. Both syntheses can be performed on a multi-gram scale. The products are obtained in pure form and can be stored as solids without decomposition. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.