103175-61-7

Upstream product

• 37885-41-9 2',4'-dichloropropiophenone 
• 6574-98-7 2,4-dichlorobenzylnitrile 

Downstream Products

• 502159-70-8 4-(2,4-dichloro-phenyl)-2-[1-(2,4-dichloro-phenyl)-cyclopropyl]-5-methyl-1H-imidazole 
• 765278-98-6 2-phenyl-4-(2,4-dichlorophenyl)-5-methylimidazole 
• 1321959-65-2 4-(2,4-dichlorophenyl)-5-methyl-N-(naphthalen-1-yl)thiazol-2-amine 
• 1321959-77-6 N₁-(4-(2,4-dichlorophenyl)-5-methylthiazol-2-yl)benzene-1,4-diamine 
• 1609483-25-1 ethyl 5-(2,4-dichlorophenyl)-1-(4-(2,4-dichlorophenyl)-5-methylthiazol-2-yl)-4-methyl-1H-pyrazole-3-carboxylate 
• 1609483-23-9 ethyl 5-(4-chlorophenyl)-1-(4-(2,4-dichlorophenyl)-5-methylthiazol-2-yl)-4-methyl-1H-pyrazole-3-carboxylate 
• 1609483-14-8 ethyl 1-(4-(2,4-dichlorophenyl)-5-methylthiazol-2-yl)-5-phenyl-1H-pyrazole-3-carboxylate 
• 1207259-62-8 5-[2-(2,4-dichloro-phenyl)-1-methyl-2-oxo-ethoxy]-3-ethyl-1H-pyrazole-4-carboxylic acid ethyl ester 
• 1207259-37-7 1-(2,4-dichloro-phenyl)-2-(5-ethyl-2H-pyrazol-3-yloxy)-propan-1-one 
• 1207259-14-0 1-(2,4-dichlorophenyl)-2-(4-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-3-methyl-1H-pyrazol-5-yloxy)propan-1-one 
• 1207259-13-9 1-(2,4-Dichloro-phenyl)-2-(5'-methyl-3-trifluoromethyl-2'H-[1,4']bipyrazolyl-3'-yloxy)-propan-1-one 

Relevant academic research and scientific papers

Synthesis of three imidazole derivatives and corrosion inhibition performance for copper

Three imidazole derivatives, including 3-(4-(2,4-dichlorophenyl)-5-methyl-1H-imidazol-2-yl)pyridine (PDI), 2-(4-(2,4-dichlorophenyl)-5-methyl-1H-imidazol-2-yl)pyrazine (PAI) and 2-(4-(2,4-dichlorophenyl)-5-methyl-1H-imidazol-2-yl)pyrimidine (PMI), were synthesized. The structure of these compounds was confirmed by LC-MS, 1H NMR, 13C NMR and FTIR spectra. The inhibition performance in 3.5 wt% NaCl was investigated by electrochemical measurement and surface analysis. Results show that the corrosion efficiency of PDI (95.93%) was higher than PAI (69.61%) and PMI (20.46%), which is consistent with the adsorption energy calculated by molecular dynamics simulation. The corrosion inhibition mechanism could be explained by the metal–organic polymer film formed on the copper surface: on the one hand, the π-system formed by aromatic rings is tightly adsorbed on the copper substrates; on the other hand, the nitrogen atoms in the imidazole ring are coordinated with the metal ions in solution to form metal–organic polymer which could improve the compactness of the hydrophobic film.

Pyrazinyl imidazole compound, weldable protective agent and preparation method and application of pyrazinyl imidazole compound

The invention discloses a pyrazinyl imidazole compound, and the compound has the following structural formula shown in the description, wherein the pyrazinyl imidazole compound can be used as a film forming substance of an organic weldable protective agen

1,2,3-triazole structure containing enol ether compounds as antifungal agent

The invention discloses 1,2,3-triazole structure containing enol ether compounds shown in a formula (I) or pharmaceutically acceptable salts, solvates, optical isomers or polymorphic substances thereof. X is N or CH; R1 and R2 are H atoms, halogen, nitro, cyano, C1-C6 alkyl and halogenated C1-C6 alkyl, and R1 and R2 can be the same or different; R3 and R4 are H atoms, halogen, hydroxyl, an amino group, a cyano group, nitro, halogenated C1-C6 alkyl, C1-C6 alkyl, C6-C10 aryl, C4-C6 aromatic heterocyclic groups, C1-C6 alkoxy and halogenated C1-C6 alkoxy; R3 and R4 can be the same or different. Asthe antifungal agent, the 1,2,3-triazole structure containing enol ether compounds have higher killing effects on clinically common pathogenic fungi and are expected to overcome the defects of largetoxic and side effects, high drug resistance probability and the like of azole antifungal drugs widely used clinically at present.

Substituted 2-aminothiazoles are exceptional inhibitors of neuronal degeneration in tau-driven models of Alzheimer's disease

A novel series of 2-aminothiazoles with strong protection in an Alzheimer's disease (AD) model comprising tau-induced neuronal toxicity is disclosed. These derivatives can be synthesized in one-pot and a small SAR of the substitution within these series afforded several compounds that counteracted tau-induced cell toxicity at nanomolar concentrations. These congeners therefore have strong potential as possible treatment for Alzheimer's disease and other related tauopathies.

Organic compounds

There are described pyrazolo[5.1-b]oxazole derivatives useful as corticotropin releasing factor (CRF1) receptor antagonists.

Pyrrole derivatives and medicinal composition

The invention relates to a pharmaceutical composition comprising a pyrrole derivative of the following formula [1] or a pharmaceutically acceptable salt thereof, or a solvate of either of them, as an active ingredient. STR1 (wherein R1 represents hydrogen or alkoxycar91 bonylamino, R2 represents alkyl, aryl which may be substituted, aromatic heterocyclyl which may be substituted, unsubstituted amino, monoalkylamino, dialkylamino, or cyclic amino which may be substituted; R3 represents cyano or carbamoyl; R4 represents hydrogen or alkyl; E represents alkylene; q is equal to 0 or 1, A represents methyl, aryl which may be substituted, or aromatic heterocyclyl which may be substituted). The pharmaceutical composition of the invention is effective for the treatment of pollakiuria or urinary incontinence.

Branched alkylamino derivatives of thiazole, processes for preparing them and pharmaceutical compositions containing them

The invention relates to the derivatives of formula I: STR1 in which R1 represents a phenyl or naphthyl radical (optionally substituted), R2 represents a hydrogen or halogen atom or an alkyl, hydroxymethyl or formyl radical, R3

Heterocyclic compounds

A compound having the general formula: STR1 and stereoisomers thereof, wherein R1 is alkyl, alkenyl, alkynyl, cycloalkyl or cycloalkenyl, all having up to 8 carbon atoms; or is aryl, aralkyl or heterocyclyl, any of which may be optionally subst