103175-61-7Relevant articles and documents
Synthesis of three imidazole derivatives and corrosion inhibition performance for copper
He, Kang,Hou, Yanggao,Lei, Jiaheng,Ma, Sicai,Yang, Ze,Zhu, Limeng
, (2022/01/26)
Three imidazole derivatives, including 3-(4-(2,4-dichlorophenyl)-5-methyl-1H-imidazol-2-yl)pyridine (PDI), 2-(4-(2,4-dichlorophenyl)-5-methyl-1H-imidazol-2-yl)pyrazine (PAI) and 2-(4-(2,4-dichlorophenyl)-5-methyl-1H-imidazol-2-yl)pyrimidine (PMI), were synthesized. The structure of these compounds was confirmed by LC-MS, 1H NMR, 13C NMR and FTIR spectra. The inhibition performance in 3.5 wt% NaCl was investigated by electrochemical measurement and surface analysis. Results show that the corrosion efficiency of PDI (95.93%) was higher than PAI (69.61%) and PMI (20.46%), which is consistent with the adsorption energy calculated by molecular dynamics simulation. The corrosion inhibition mechanism could be explained by the metal–organic polymer film formed on the copper surface: on the one hand, the π-system formed by aromatic rings is tightly adsorbed on the copper substrates; on the other hand, the nitrogen atoms in the imidazole ring are coordinated with the metal ions in solution to form metal–organic polymer which could improve the compactness of the hydrophobic film.
1,2,3-triazole structure containing enol ether compounds as antifungal agent
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Paragraph 0042; 0043; 0044, (2018/09/12)
The invention discloses 1,2,3-triazole structure containing enol ether compounds shown in a formula (I) or pharmaceutically acceptable salts, solvates, optical isomers or polymorphic substances thereof. X is N or CH; R1 and R2 are H atoms, halogen, nitro, cyano, C1-C6 alkyl and halogenated C1-C6 alkyl, and R1 and R2 can be the same or different; R3 and R4 are H atoms, halogen, hydroxyl, an amino group, a cyano group, nitro, halogenated C1-C6 alkyl, C1-C6 alkyl, C6-C10 aryl, C4-C6 aromatic heterocyclic groups, C1-C6 alkoxy and halogenated C1-C6 alkoxy; R3 and R4 can be the same or different. Asthe antifungal agent, the 1,2,3-triazole structure containing enol ether compounds have higher killing effects on clinically common pathogenic fungi and are expected to overcome the defects of largetoxic and side effects, high drug resistance probability and the like of azole antifungal drugs widely used clinically at present.
Organic compounds
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Page/Page column 61, (2010/03/02)
There are described pyrazolo[5.1-b]oxazole derivatives useful as corticotropin releasing factor (CRF1) receptor antagonists.