1031771-50-2Relevant academic research and scientific papers
Inhibition of HIV fusion with multivalent gold nanoparticles
Bowman, Mary-Catherine,Ballard, T. Eric,Ackerson, Christopher J.,Feldheim, Daniel L.,Margolis, David M.,Melander, Christian
, p. 6896 - 6897 (2008)
The design and synthesis of a multivalent gold nanoparticle therapeutic is presented. SDC-1721, a fragment of the potent HIV inhibitor TAK-779, was synthesized and conjugated to 2.0 nm diameter gold nanoparticles. Free SDC-1721 had no inhibitory effect on HIV infection; however, the (SDC-1721)-gold nanoparticle conjugates displayed activity comparable to that of TAK-779. This result suggests that multivalent presentation of small molecules on gold nanoparticle surfaces can convert inactive drugs into potent therapeutics. Copyright
