1031773-04-2

Basic information

• Product Name: 5-amino-8-benzoyl-2-methyl-7-(4-nitrophenyl)-7H-[1,3,4]thiadiazolo[3,2-a]pyridine-6-carbonitrile
• Synonyms: 5-amino-8-benzoyl-2-methyl-7-(4-nitrophenyl)-7H-[1,3,4]thiadiazolo[3,2-a]pyridine-6-carbonitrile
• CAS NO: 1031773-04-2
• Molecular Weight: 417.448
• Mol File: 1031773-04-2.mol

Chemical Properties

• CAS DataBase Reference: 5-amino-8-benzoyl-2-methyl-7-(4-nitrophenyl)-7H-[1,3,4]thiadiazolo[3,2-a]pyridine-6-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 5-amino-8-benzoyl-2-methyl-7-(4-nitrophenyl)-7H-[1,3,4]thiadiazolo[3,2-a]pyridine-6-carbonitrile(1031773-04-2)
• EPA Substance Registry System: 5-amino-8-benzoyl-2-methyl-7-(4-nitrophenyl)-7H-[1,3,4]thiadiazolo[3,2-a]pyridine-6-carbonitrile(1031773-04-2)

Safety Data

• Hazardous Substances Data: 1031773-04-2(Hazardous Substances Data)

Upstream product

• 555-16-8 4-nitrobenzaldehdye 
• 109-77-3 malononitrile 
• 125488-04-2 2-methyl-5-phenacyl-1,3,4-thiadiazole 

Relevant articles and documents

One-pot, three-component synthesis of 7H-[1,3,4]thiadiazolo[3,2-fl] pyridines from 2-phenacyl-[1,3,4]thiadiazole derivatives and arylmethylene-cyanoacetic acid derivatives

Generally, arylmethylene-cyanoacetic acid derivatives react with enols and aromatic or heteroaromatic hydroxy compounds to afford 2-amino-4H-pyran derivatives of type 6. In contrast, a ring closure with the nitrogen atom of the thiadiazole ring occurs when 2-phenacyl-1,3,4-thiadiazoles (1a-d) act on derivatives of arylmethylene-cyanoacetic acid giving rise to the formation of 777-[1,3,4]thiazolo[3,2-a]pyridine derivatives 5a -r. The same products are obtained if 2-phenacyl-1,3,4thiadiazoles react with aromatic or heteroaromatic aldehydes and cyanoacetic acid derivatives. The constitution of the novel compounds 5 has been confirmed by an X-ray analysis of 5a.