10318-26-0

Basic information

• Product Name: DIBROMODULCITOL
• Synonyms: Dibromdulcitol;DIBROMODULCITOL;1,6-dibromo-1,6-dideoxy-d-galactitol;1,6-dibromo-1,6-dideoxydulcitol;1,6-dibromo-1,6-dideoxy-galactito;1,6-dibromo-1,6-dideoxygalactitol;1,6-Dibromodideoxydulcitol;1,6-Dibromodulcitol
• CAS NO: 10318-26-0
• Molecular Formula: C6H12Br2O6
• Molecular Weight: 339.96388
• EINECS: 207-676-8
• Mol File: 10318-26-0.mol
• Article Data: 9

Chemical Properties

• Melting Point: 187-188° (dec)
• Boiling Point: 511.2°Cat760mmHg
• Flash Point: 263°C
• Appearance: /
• Density: 1.8987 (rough estimate)
• Vapor Pressure: 1.37E-12mmHg at 25°C
• Refractive Index: 1.4840 (estimate)
• PKA: 12.61±0.20(Predicted)
• Water Solubility: Insoluble (<0.1 g/100 mL)
• CAS DataBase Reference: DIBROMODULCITOL(CAS DataBase Reference)
• NIST Chemistry Reference: DIBROMODULCITOL(10318-26-0)
• EPA Substance Registry System: DIBROMODULCITOL(10318-26-0)

Safety Data

• Hazardous Substances Data: 10318-26-0(Hazardous Substances Data)

Usage

Uses

1,6-Dibromodulcitol is an intermediate in the synthesis of Dulcitol Diepoxide (D720515). Dulcitol Diepoxide is a cytostatic drug. Dulcitol Diepoxide can be used for treatment of leukemia, lung cancer, multiple myeloma, and nasopharyngeal carcinoma.

General Description

White powder. Insoluble in water.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

A halogenated alcohol. Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents. They react with oxoacids and carboxylic acids to form esters plus water. Oxidizing agents convert them to aldehydes or ketones. Alcohols exhibit both weak acid and weak base behavior. They may initiate the polymerization of isocyanates and epoxides.

Health Hazard

ACUTE/CHRONIC HAZARDS: DIBROMODULCITOL is toxic when ingested.

Fire Hazard

Data is not available for DIBROMODULCITOL, but DIBROMODULCITOL is probably combustible.

Safety Profile

Poison by ingestion. Moderately toxic by intraperitoneal route. Questionable carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. Human mutation data reported. An anti-cancer agent taken orally. When heated to decomposition it emits very toxic fumes of Br-.

InChI:InChI=1/C6H12Br2O4/c7-1-3(9)5(11)6(12)4(10)2-8/h3-6,9-12H,1-2H2/t3-,4+,5+,6-

Upstream product

• 608-66-2 D-galactitol 

Downstream Products

• 15410-52-3 tetra-O-acetyl-1,6-dibromo-1,6-dideoxy-galactitol 
• 33471-05-5 3,6-anhydro-1-bromo-1-deoxy-DL-galactitol 
• 33471-05-5 3,6-anhydro-1-bromo-1-deoxy-DL-galactitol 
• 15430-94-1 1-bromo-1-deoxy-DL-galactitol 
• 23261-25-8 1,6-Didesoxy-1,6-diiod-D-galaktitol 

Related news

The effect of DIBROMODULCITOL (cas 10318-26-0) on resting and dividing lymphoid cells08/04/2019

The effect of dibromodulcitol (DBD) on the incorporation of labelled precursors into DNA and RNA fractions of PHA-stimulated human lymphocytes and of P388F lymphoma cells at various stages of their growth was studied. Both cell systems showed sensitivity to the drug within the concentration rang...detailed

The distribution of bromine content of DIBROMODULCITOL (cas 10318-26-0) in the central nervous system of patients with malignant gliomas08/03/2019

The bromine content of human gliomas and white matter was determined by neutron activation analysis (NAA) following p.o. administration of a single dose of 400–500 mg/m2 dibromodulcitol (DBD). In another group of patients with brain gliomas, the bromine content was measured subsequent to applic...detailed

Adjuvant DIBROMODULCITOL (cas 10318-26-0) and BCNU chemotherapy in anaplastic astrocytoma: Results of a randomised European Organisation for Research and Treatment of Cancer phase III study (EORTC study 26882)07/29/2019

BackgroundIn a previous randomised EORTC study on adjuvant dibromodulcitol (DBD) and bichloroethylnitrosourea (BCNU) in adults with glioblastoma multiforme (GBM) and anaplastic astrocytoma (AA), a clinically significant trend towards a longer overall survival (OS) and a progression-free survival...detailed

Identification of guanine and adenine adducts in DNA alkylated by DIBROMODULCITOL (cas 10318-26-0) in vitro and in vivo07/28/2019

DNA reacted with dibromodulcitol in neutral solution yielded 3- and 7-alkyl substituted purines after hydrolysis at neutral pH-value at 37°C. The alkylated products were identified by mass spectrometry and by comparison of their UV absorption spectra and chromatographic properties on thin-layer...detailed

Relevant articles and documents

Synthetic method of dibromodulcitol

The invention relates to a method for preparing dibromodulcitol. The method for preparing dibromodulcitol is used, the reaction product whose average yield is 50% or above and average purity is 80% or above is obtained, and especially in a preferable range, the purity reaches 95% or above; and compared with the prior art, the effect is obviously better.

Application of cation exchange resin to improvement of yield in bromination reaction of hexanehexol

The invention relates to an application of cation exchange resin to a bromination reaction of hexanehexol. Yield of dibromohexanehexol is substantially increased in the preparation processes of dibromohexanehexol from hexanehexol by using the cation exchange resin, and the effects are obviously better than the effects in the prior art.