103202-62-6Relevant academic research and scientific papers
Synthesis and immunological evaluation of a low molecular weight saccharide with TLR-4 agonist activity
Basava, Vikram,Romlein, Heather,Bitsaktsis, Constantine,Marzabadi, Cecilia H.
, p. 697 - 705 (2017/01/03)
The paucity of FDA approved adjuvants renders the synthesis, characterization, and use of new compounds as vaccine adjuvants, a necessity. For this purpose, a novel saccharide analog has been synthesized from glucosamine, pyruvylated galactose and 1,4-cyclohexanediol and its biological efficacy was determined in innate immune cells. More specifically, we assessed the production of pro-inflammatory cytokines from the murine monocyte cell line, Raw 264.7 and from C57 BL/6 mouse peritoneal macrophages following exposure to the saccharide analog. Our data conclude that the novel saccharide has immunostimulatory activity on mouse macrophages as indicated by the elevated levels of IL-6 and TNF-α in culture supernatants. This effect was TLR-4-dependent but TLR-2-independent. Our data, suggest TLR-4 agonism; a key feature of vaccine adjuvants.
HETEROCYCLIC COMPOUND
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Paragraph 0493, (2015/04/15)
The present invention provides a compound having a superior JAK inhibitory action, which is useful as an agent for the prophylaxis or treatment of autoimmune diseases (rheumatoid arthritis, psoriasis, inflammatory bowel disease, Sjogren's syndrome, Behcet's disease, multiple sclerosis, systemic lupus erythematosus, etc.), cancer (leukemia, uterine leiomyosarcoma, prostate cancer, multiple myeloma, cachexia, myelofibrosis, etc.) and the like, or a salt thereof. The present invention relates to a compound represented by the formula wherein each symbol is as defined in the specification, or a salt thereof.
Hexanes/acetonitrile: A binary solvent system for the efficient monosilylation of symmetric primary and secondary diols
Wilke, Burkhardt I.,Dornan, Mark H.,Yeung, Jon,Boddy, Christopher N.,Pinto, Atahualpa
, p. 2600 - 2602 (2014/05/06)
Symmetric diols are useful compounds in the synthesis of natural products, their value often dependent on their successful monoprotection. A general and simple method for the monosilylation of symmetrical primary and secondary diols is reported. The metho
SPIROINDOLINONE DERIVATIVES
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Page/Page column 76, (2009/07/03)
There are provided compounds of the formula and pharmaceutically acceptable salts and esters thereof wherein W, V, X, Y, A, R and R' are as described herein. The compounds are useful as anticancer agents.
