103203-47-0 Usage
Description
1-(4-ethyl-3-nitrophenyl)ethanone, also known as p-Nitropropacetamol, is a chemical compound with the molecular formula C11H13NO3. It is a derivative of acetaminophen, featuring a nitro substitution on the para position of the phenyl ring. 1-(4-ethyl-3-nitrophenyl)ethanone is characterized by its analgesic and antipyretic properties, which are similar to those of acetaminophen.
Uses
Used in Pharmaceutical Industry:
1-(4-ethyl-3-nitrophenyl)ethanone is used as an analgesic and antipyretic drug for the treatment of moderate to severe pain and fever. Its mechanism of action is believed to involve the inhibition of prostaglandin synthesis in the central nervous system, similar to acetaminophen. Additionally, p-Nitropropacetamol is metabolized into its active form, p-aminophenol, in the body, which contributes to its therapeutic effects.
Used in Pain Management:
1-(4-ethyl-3-nitrophenyl)ethanone serves as an effective pain reliever, addressing a wide range of pain conditions. Its efficacy in pain management is attributed to its ability to inhibit prostaglandin synthesis, a key factor in pain perception and inflammation.
Used in Fever Reduction:
As an antipyretic, 1-(4-ethyl-3-nitrophenyl)ethanone helps to reduce fever by lowering the body's temperature set point. This is particularly useful in cases of fever caused by infections or other inflammatory conditions.
Used in Trade Name Products:
1-(4-ethyl-3-nitrophenyl)ethanone is marketed under various trade names, making it accessible to consumers and healthcare providers for the treatment of pain and fever. Its availability in different formulations allows for flexibility in dosage and administration, catering to individual patient needs.
Check Digit Verification of cas no
The CAS Registry Mumber 103203-47-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,3,2,0 and 3 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 103203-47:
(8*1)+(7*0)+(6*3)+(5*2)+(4*0)+(3*3)+(2*4)+(1*7)=60
60 % 10 = 0
So 103203-47-0 is a valid CAS Registry Number.
103203-47-0Relevant articles and documents
Dichloroacetophenones targeting at pyruvate dehydrogenase kinase 1 with improved selectivity and antiproliferative activity: Synthesis and structure-activity relationships
Zhang, Shao-Lin,Yang, Zheng,Hu, Xiaohui,Tam, Kin Yip
supporting information, p. 3441 - 3445 (2018/09/29)
Dichloroacetophenone is a pyruvate dehydrogenase kinase 1 (PDK1) inhibitor with suboptimal kinase selectivity. Herein, we report the synthesis and biological evaluation of a series of novel dichloroacetophenones. Structure-activity relationship analyses (SARs) enabled us to identify three potent compounds, namely 54, 55, and 64, which inhibited PDK1 function, activated pyruvate dehydrogenase complex, and reduced the proliferation of NCI-H1975 cells. Mitochondrial bioenergetics assay suggested that 54, 55, and 64 enhanced the oxidative phosphorylation in cancer cells, which might contribute to the observed anti-proliferation effects. Collectively, these results suggested that 54, 55, and 64 could be promising compounds for the development of potent PDK1 inhibitors.
CINNOLINE AND QUINAZOLINE DERIVATES AS PHOSPHODIESTERASE 10 INHIBITORS
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Page/Page column 56, (2010/11/28)
The present invention is directed to cinnoline and quinazoline compounds of formula (I) that are PDE10 inhibitors, pharmaceutical compounds containing the same and processes for preparing the same. The invention is also directed to methods of treating diseases mediated by PDE10 enzyme such as obesity, non-insulin dependent diabetes, schizophrenia or bipolar disorder, obsessive-compulsive disorder, and the like.
