1032047-47-4Relevant articles and documents
N-[6-Amino-2-(heteroaryl)pyrimidin-4-yl]acetamides as A2A receptor antagonists with improved drug like properties and in vivo efficacy
Lanier, Marion C.,Moorjani, Manisha,Luo, Zhiyong,Chen, Yongsheng,Lin, Emily,Tellew, John E.,Zhang, Xiaohu,Williams, John P.,Gross, Raymond S.,Lechner, Sandra M.,Markison, Stacy,Joswig, Tanya,Kargo, William,Piercey, Jaime,Santos, Mark,Malany, Siobhan,Zhao, Marilyn,Petroski, Robert,Crespo, María I.,Díaz, José-Luis,Saunders, John,Wen, Jenny,O'Brien, Zhihong,Jalali, Kayvon,Madan, Ajay,Slee, Deborah H.
experimental part, p. 709 - 717 (2009/12/05)
In the present article, we report on a strategy to improve the physical properties of a series of small molecule human adenosine 2A (hA2A) antagonists. One of the aromatic rings typical of this series of antagonists is replaced with a series of