1032065-37-4

Basic information

• Product Name: 2,3,4-triphenyl-2H-pyrazolo[3,4-d]pyridazin-7-yl-amine
• Synonyms: 2,3,4-triphenyl-2H-pyrazolo[3,4-d]pyridazin-7-yl-amine
• CAS NO: 1032065-37-4
• Molecular Weight: 363.421
• Mol File: 1032065-37-4.mol

Chemical Properties

• CAS DataBase Reference: 2,3,4-triphenyl-2H-pyrazolo[3,4-d]pyridazin-7-yl-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3,4-triphenyl-2H-pyrazolo[3,4-d]pyridazin-7-yl-amine(1032065-37-4)
• EPA Substance Registry System: 2,3,4-triphenyl-2H-pyrazolo[3,4-d]pyridazin-7-yl-amine(1032065-37-4)

Safety Data

• Hazardous Substances Data: 1032065-37-4(Hazardous Substances Data)

Upstream product

• 1032065-36-3 4-benzoyl-1,5-diphenyl-1H-pyrazole-3-carbonitrile 

Relevant articles and documents

Further derivatives of 4-benzoyl-1,5-diphenyl-1H-pyrazole-3-carboxylic acid and their antibacterial activities

Compound 4, 5, 6, 7, and 8 were synthesized from 4-benzoyl-1,5-diphenyl-1H- pyrazole-3-carboxylic acid 1 as a starting material. The pyrazolo[4,3-d] oxazinone 4 was obtained from direct reaction of the acid 1 with hydroxylamine hydrochloride. Acid chloride 2 was converted easily into the new derivatives consisting of 1-(4-benzoyl-1,5-diphenyl-1H-pyrazol-3-oyl)-sulfamide 5 and 3,4-dibenzoyl-1,5-diphenyl-1H-pyrazole 6. The nitrile derivative 7 was obtained by dehydration of the amide 3 in a mixture of SOCl2 and Dimethylformamide (DMF). Cyclocondensation reaction of 7 with anhydrous hydrazine led to the formation of 7-aminopyrazolo[3,4-d]pyridazine 8 derivative. These new synthesized compounds evaluated for their antibacterial activities against Gram-positive and Gram-negative bacteria using the tube dilution method. The finding of antibacterial activity study showed that the sulfamide derivative 5 was the best compound of the series, exhibiting antibacterial activity against both Gram-positive and Gram-negative bacteria.