1032180-02-1

Basic information

• Product Name: azido(2-phenyloxazol-4-yl)methanone
• Synonyms: azido(2-phenyloxazol-4-yl)methanone
• CAS NO: 1032180-02-1
• Molecular Weight: 214.183
• Mol File: 1032180-02-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: azido(2-phenyloxazol-4-yl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: azido(2-phenyloxazol-4-yl)methanone(1032180-02-1)
• EPA Substance Registry System: azido(2-phenyloxazol-4-yl)methanone(1032180-02-1)

Safety Data

• Hazardous Substances Data: 1032180-02-1(Hazardous Substances Data)

Upstream product

• 1204-70-2 2-phenyl-1,3-oxazole-4-carbonyl chloride 
• 90946-23-9 2-phenyloxazole-4-carbohydrazide 
• 55-21-0 benzamide 
• 39819-39-1 2-phenyl-oxazole-4-carboxylic acid ethyl ester 

Downstream Products

• 1019328-58-5 1-phenyl-3-(2-phenyloxazol-4-yl)urea 
• 100062-15-5 (2-phenyl-oxazol-4-yl)-carbamic acid 2-chloro-ethyl ester 
• 100394-87-4 1-allyl-3-(2-phenyl-oxazol-4-yl)-urea 
• 101424-22-0 1-cyclohexyl-3-(2-phenyl-oxazol-4-yl)-urea 
• 120037-23-2 N-(2-phenyl-oxazol-4-ylcarbamoyl)-glycine 
• 107203-69-0 1-(3-dimethylamino-propyl)-3-(2-phenyl-oxazol-4-yl)-urea 
• 100973-60-2 piperidine-1-carboxylic acid 2-phenyl-oxazol-4-ylamide 
• 121576-24-7 4-Isocyanato-2-phenyl-oxazol 
• 101289-11-6 (2-phenyl-oxazol-4-yl)-carbamic acid cyclohexyl ester 
• 32512-42-8 benzyl 2-phenyl-4-oxazolecarbamate 

Relevant articles and documents

Synthesis and Molecular Docking Studies of Novel 2-Phenyl-4-Substituted Oxazole Derivatives as Potential Anti-cancer Agents

(Figure presented) A novel series of 2,4-disubstituted oxazole derivatives were synthesized, screened for their anti-tumor activity against three cell lines MCF-7, TK-10, and UACC-62. Molecular docking study was carried out against epidermal growth factor receptor. A new series of 2-phenyl-4-substituted oxazole derivatives were synthesized. A series of chiral α-amino acid derivatives 6, 7, 8, 9, 10, 11, 12, 13, 14, 15 were synthesized by coupling various l-acylated amino acid azide 3. The synthesized compounds were tested for their in vitro antitumor activity against MCF-7, TK-10, and UACC-62 cell lines. Compound 6 exhibited the strongest inhibitory activity against TK cell lines, while compound 12 showed the highest activity against MCF-7 cell lines. Compound 14 was the most active against UACC-62 cell lines. Furthermore, a molecular docking study of the most active compounds was carried out using epidermal growth factor receptor X-ray 3D structure (protein data bank ID 1 M17). Docking results revealed that compound 6 showed the highest binding energy of ΔG = -78.17 Kcal/mol.