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103220-12-8

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103220-12-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 103220-12-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,3,2,2 and 0 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 103220-12:
(8*1)+(7*0)+(6*3)+(5*2)+(4*2)+(3*0)+(2*1)+(1*2)=48
48 % 10 = 8
So 103220-12-8 is a valid CAS Registry Number.

103220-12-8Relevant articles and documents

Parimycin: Isolation and structure elucidation of a novel cytotoxic 2,3-dihydroquinizarin analogue of γ-indomycinone from a marine Streptomycete isolate

Maskey, Rajendra P.,Helmke, Elisabeth,Fiebig, Heinz-Herbert,Laatsch, Hartmut

, p. 1031 - 1035 (2002)

In our screening of actinomycetes from the marine environment for bioactive components, a new antibiotic with a novel structure designated as parimycin was obtained from the culture broth of Streptomyces sp. isolate B8652. The structure of the new antibiotic was determined by spectroscopic methods and by comparison of the NMR data with those of the structurally related γ-indomycinone.

One- and Two-electron Reduction of Quinizarin and 5-Methoxyquinizarin: A Pulse Radiolysis Study

Mukherjee, Tulsi,Swallow, A. John,Guyan, Patricia M.,Bruce, J. Malcolm

, p. 1483 - 1491 (1990)

Absorption characteristics of the semiquinone free radicals formed by one-electron reduction of quinizarin (QH2), 5-methoxyquinizarin (MQH2) and quinizarin 2-sulphonate (QSH2) have been studied by pulse radiolysis in a mixed solvent system consisting of water, isopropyl alcohol and acetone.Second-order rate constants have been determined for the reactions of (CH3)2COH with the quinones, of the semiquinone with O2 and of the semiquinones with each other.The one-electron reduction potentials (vs.NHE) are E17 = -269 mV for QH2, -333 mV for MQH2 and -298 mV for QSH2.They vary with pH in accordance with the pKa values of the parent quinones and the semiquinones.The radicals are stable within the approximate pH range 5-11.The stability constant is highest at pH 8.5 (Ks = 0.09) for QH2, at pH = 9.5 for QSH2 (Ks = 10) and pH = 10.8 for MQH2 (Ks = 4.8), respectively.The one-electron reduction potentials of the semiquinones and the two-electron reduction potentials of the quinones are calculated to be E27 = -188, -192 and -216 mV, and Em7 = -229, -263 and -257 mV for QH2, MQH2 and QSH2, respectively.The effect of solvent on the properties of the semiquinones is discussed.

Photochemical Hydroxylation of Anthracene-9,10-dione in Sulphuric Acid Solution

Broadbent, A. Douglas,Stewart, John M.

, p. 676 - 677 (1980)

Near u.v. irradiation of anthracene-9,10-dione in deoxygenated 96percent H2SO4 generates the sulphate ester of 2-hydroxyanthracene-9,10-dione in high yield along with the 1-hydroxy isomer and the novel reduction products anthracen-9(10H)-one and 9,9'-bianthracene-10,10'(9H,9'H)-dione; contrary to previous results, the product distribution and the rate of reaction are dependent upon the concentration of O2 in the solution.

Combined spectral experiment and theoretical calculation to study the interaction of 1,4-dihydroxyanthraquinone for metal ions in solution

Yin, Caixia,Zhang, Jingjing,Huo, Fangjun

, p. 772 - 777 (2013)

The interaction between 1,4-dihydroxyanthraquinone (1,4-DHA) and metal ions was studied by UV-Visible and fluorescence spectroscopies in solution. Time-dependent density functional theory calculations confirmed complex structures. The investigation results showed 1,4-DHA can selectively respond some metal ions and can be monitored by UV-Vis, fluorescence spectra and naked-eye. So 1,4-DHA has a potential application in the design of metal ions probe. More, as typical metal ions, Hg2+ and Er3+, their reaction abilities for 1,4-DHA were studied in detailed. Experimental results showed they have better response for 1,4-DHA. And theoretical calculation concluded that Er3+ easily reacts with 1,4-DHA over Hg2+ attributed to the low reaction energy of Er3+-1,4-DHA than Hg 2+-1,4-DHA.

Thermodynamics of semiquinone disproportionation in aqueous buffer

Alegria, Antonio E.,Lopez, Marcos,Guevara, Norberto

, p. 4965 - 4968 (1996)

The thermodynamic parameters, Kdisp, ΔH° and ΔS°, controlling the disproportionation of semiquinones derived from 1,4-benzoquinone (BQ), 1,4-naphthoquinone (NQ), 2-methylbenzoquinone (MBQ), menadione (MNQ), naphthazarin (NZQ) and quinizarin (QNZ), have been determined. Smaller disproportionation constants, Kdisp, are observed upon addition of a fused benzene ring to the semiquinone structure. Negative enthalpies and positive entropies of disproportionation govern the disproportionation equilibria. Addition of OH groups to the 5 and 8 positions in NQ?- displaces the disproportionation equilibrium to the semiquinone probably due to intramolecular hydrogen bonding.

Visible-light photocatalytic activity of chitosan/polyaniline/CdS nanocomposite: Kinetic studies and artificial neural network modeling

Rasoulifard,Seyed Dorraji,Amani-Ghadim,Keshavarz-Babaeinezhad

, p. 60 - 70 (2016)

Chitosan/polyaniline (CS/PAni), chitosan/CdS (CS/CdS) and chitosan/polyaniline/CdS nanocomposite were synthesized and characterized using X-ray diffraction pattern analysis, FT-IR spectroscopy and scanning electronic microscopy. The adsorption performance and photocatalytic activity of CS/PAni/CdS was compared with CS/PAni and CS/CdS in the removal of Reactive Blue 19 (RB19) dye. After five cycles of experiments under visible light irradiation, CS/PAni/CdS retained high photocatalytic activity which confirmed good stability of nanocomposite. Moreover, the kinetics of decolorization was investigated and novel equation rate for dye removal was established by considering two parallel mechanisms including adsorption and surface photocatalytic degradation of dye by CS/PAni/CdS. Artificial neural network was employed to develop a model for predicting the decolorization efficiency and determining the relative importance of operational parameters. A 3-layer perceptron network with optimized 5:10:1 topology could provide adequate predictive performance (R2 = 0.983). Moreover, the photocatalytic degradation of RB19 was monitored by measuring the total organic carbon (TOC) and GC-MS analysis, enabling the evaluating the mineralization and identifying the intermediates. During 120 min of experiment, more than 80% of TOC was removed.

Oxidative Coupling of Furans and Naphthoquinones: a Potential Route to Anthracyclinones

Bridson, John N.,Bennett, Sharon M.,Butler, Gary

, p. 413 - 414 (1980)

2-Furyl-1,4-naphthoquinones have been prepared by treatment of mixtures of furans and naphthoquinones with chloranil and other oxidants, and used to synthesize quinizarin and 6,11-dihydroxynaphthacene-5,12-dione in a reaction sequence which promises great versatility.

Synthesis method of orange intermediate

-

Paragraph 0029-0039, (2020/10/21)

The invention discloses a synthesis method of an orange intermediate, and belongs to the field of orange intermediates. The synthesis method of the orange intermediate comprises the following steps: 1, preparing 106-110% sulfuric acid as a solvent; 2, adding p-chlorophenol and excessive phthalic anhydride into a clean reaction container, adding a catalyst boric anhydride, and pouring the sulfuricacid solvent obtained in step 1 into the reaction container; 3, heating the reaction container to 190-200 DEG C, and reacting the p-chlorophenol and phthalic anhydride added in step 2 under the actionof a catalyst; and 4, after the reaction is finished, cooling, diluting, separating out upper wastewater, and filtering to obtain the orange intermediate. According to the scheme, 106-110% sulfuric acid is adopted as the solvent, boric anhydride is adopted as the catalyst, and hydrolysis of phthalic anhydride can be greatly reduced, so the use amount of phthalic anhydride is reduced, the yield isgreatly increased, phthalic anhydride is recycled, and COD of three wastes is greatly reduced.

Evaluation of a series of 9,10-anthraquinones as antiplasmodial agents

Osman, Che Puteh,Ismail, Nor Hadiani,Widyawaruyanti, Aty,Imran, Syahrul,Tumewu, Lidya,Choo, Chee Yan,Ideris, Sharinah

, p. 353 - 363 (2019/06/20)

Background: A phytochemical study on medicinal plants used for the treatment of fever and malaria in Africa yielded metabolites with potential antiplasmodial activity, many of which are Anthraquinones (AQ). AQs have similar sub-structure as naphthoquinones and xanthones, which were previously reported as novel antiplasmodial agents. Objective: The present study aimed to investigate the structural requirements of 9,10-anthraquinones with hydroxy, methoxy and methyl substituents to exert strong antiplasmodial activity and to investigate their possible mode of action. Methods: Thirty-one AQs were synthesized through Friedel-Crafts reaction and assayed for antiplasmodial activity in vitro against Plasmodium falciparum (3D7). The selected compounds were tested for toxicity and probed for their mode of action against β-hematin dimerization through HRP2 and lipid catalyses. The most active compounds were subjected to a docking study using AutoDock 4.2. Results: The active AQs have similar common structural characteristics. However, it is difficult to establish a structure-activity relationship as certain compounds are active despite the absence of the structural features exhibited by other active AQs. They have either ortho- or meta-arranged substituents and one free hydroxyl and/or carbonyl groups. When C-6 is substituted with a methyl group, the activity of AQs generally increased. 1,3-DihydroxyAQ (15) showed good antiplasmodial activity with an IC50 value of 1.08 μM, and when C-6 was substituted with a methyl group, 1,3-dihydroxy-6-methylAQ (24) showed stronger antiplasmodial activity with an IC50 value of 0.02μM, with better selectivity index. Compounds 15 and 24 showed strong HRP2 activity and mild toxicity against hepatocyte cells. Molecular docking studies showed that the hydroxyl groups at the ortho (23) and meta (24) positions are able to form hydrogen bonds with heme, of 3.49 A and 3.02 A, respectively. Conclusion: The activity of 1,3-dihydroxy-6-methylAQ (24) could be due to their inhibition against the free heme dimerization by inhibiting the HRP2 protein. It was further observed that the anthraquinone moiety of compound 24 bind in parallel to the heme ring through hydrophobic interactions, thus preventing crystallization of heme into hemozoin.

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