1032229-33-6 Usage
Uses
4-(2-Chlorophenoxy)-N-[3-[(methylamino)carbonyl]phenyl]-1-piperidinecarboxamide is a stearoyl-CoA desaturase 1 (SCD1) inhibitor.
Biological Activity
a939572 is a potent and orally bioavailable inhibitor of stearoyl-coa desaturase1 (scd1) with ic50 value of 37nm [1].scd is a microsomal enzyme that catalyzes the biosynthesis of monounsaturated fatty acids. one member of scd family, scd1, is regulated by dietary and hormonal factors and is proved to play an important role in lipid metabolism and body weight control. thus, scd1 is a target for the treatment of obesity and diabetes. a939572 is a synthetic inhibitor of scd1 with improved inhibitory activity and lipophilicity than its parent compound. it shows inhibition of mouse scd1 and human scd1 with ic50 values of
references
[1] xin z, zhao h, serby m d, et al. discovery of piperidine-aryl urea-based stearoyl-coa desaturase 1 inhibitors. bioorganic & medicinal chemistry letters, 2008, 18(15): 4298-4302.
Check Digit Verification of cas no
The CAS Registry Mumber 1032229-33-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,3,2,2,2 and 9 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1032229-33:
(9*1)+(8*0)+(7*3)+(6*2)+(5*2)+(4*2)+(3*9)+(2*3)+(1*3)=96
96 % 10 = 6
So 1032229-33-6 is a valid CAS Registry Number.
1032229-33-6Relevant articles and documents
Discovery of piperidine-aryl urea-based stearoyl-CoA desaturase 1 inhibitors
Xin, Zhili,Zhao, Hongyu,Serby, Michael D.,Liu, Bo,Liu, Mei,Szczepankiewicz, Bruce G.,Nelson, Lissa T.J.,Smith, Harriet T.,Suhar, Tom S.,Janis, Rich S.,Cao, Ning,Camp, Heidi S.,Collins, Christine A.,Sham, Hing L.,Surowy, Teresa K.,Liu, Gang
scheme or table, p. 4298 - 4302 (2009/04/06)
A series of structurally novel stearoyl-CoA desaturase1 (SCD1) inhibitors has been identified via molecular scaffold manipulation. Preliminary structure-activity relationship (SAR) studies led to the discovery of potent, and orally bioavailable piperidine-aryl urea-based SCD1 inhibitors. 4-(2-Chlorophenoxy)-N-[3-(methyl carbamoyl)phenyl]piperidine-1-carboxamide 4c exhibited robust in vivo activity with dose-dependent desaturation index lowering effects.
