103226-10-4

Basic information

• Product Name: 5-FLUORO-2'-DEOXYURIDINE 5'-MONOPHOSPHATE SODIUM SALT
• Synonyms: 5-FLUORO-2'-DEOXYURIDINE 5'-MONOPHOSPHATE SODIUM SALT;5-FLUORO-2'-DEOXYURIDINE-5'-*MONOPHOSPHA TE SODIUM;5-FdUMP·Na2;5'-Uridylic acid, 2'-deoxy-5-fluoro-, disodiuM salt;2'-Deoxy-5-fluoro-5'-uridylic acid disodium salt;5-Fluoro-2’deoxyuridine 5’Monophosphate Disodium Salt;5'-Uridylic acid,2'-deoxy-5-fluoro-, disodium salt (9CI);Sodium ((2R,3S,5R)-5-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3-hydroxytetrahydrofuran-2-yl)methyl phosphate
• CAS NO: 103226-10-4
• Molecular Formula: C9H11FN2NaO8P
• Molecular Weight: 348.15
• Product Categories: Biochemicals and Reagents;Nucleosides, Nucleotides, Oligonucleotides;Nucleotide Analogs
• Mol File: 103226-10-4.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Storage Temp.: −20°C
• CAS DataBase Reference: 5-FLUORO-2'-DEOXYURIDINE 5'-MONOPHOSPHATE SODIUM SALT(CAS DataBase Reference)
• NIST Chemistry Reference: 5-FLUORO-2'-DEOXYURIDINE 5'-MONOPHOSPHATE SODIUM SALT(103226-10-4)
• EPA Substance Registry System: 5-FLUORO-2'-DEOXYURIDINE 5'-MONOPHOSPHATE SODIUM SALT(103226-10-4)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22-40
• Safety Statements: 22-36/37/39
• WGK Germany: 3
• Hazardous Substances Data: 103226-10-4(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 103226-10-4 differently. You can refer to the following data:
1. 5-Fluoro-2’deoxyuridine 5’Monophosphate is used in the preparation of diaminomitosene nucleotide derivatives with anti-neoplastic activity.
2. 5-Fluoro-2′-deoxyuridine 5′-monophosphate (FdUMP) is used extensively in studies on the activity and function of thymidylate synthase (TS).
3. 5-Fluoro-2′-deoxyuridine 5′-monophosphate sodium salt has been used as an anti-mitotic agent and is used extensively in studies on the activity and function of thymidylate synthase (TS).

Biochem/physiol Actions

5-Fluoro-2′-deoxyuridine 5′-monophosphate sodium salt (FdUMP) is an DNA synthesis inhibitor. FdUMP along with RNA synthesis inhibitor 3′-C-ethinylcytidine induces cell death in cervical cancer cells at nanomolar concentrations.