103226-10-4 Usage
Uses
Used in Pharmaceutical Industry:
5-Fluoro-2'-deoxyuridine 5'-monophosphate sodium salt is used as an intermediate in the preparation of diaminomitosene nucleotide derivatives, which possess anti-neoplastic activity. These derivatives are being developed as potential cancer therapeutics, targeting the inhibition of key enzymes involved in DNA synthesis and repair.
Used in Research Applications:
FdUMP is extensively used in studies on the activity and function of thymidylate synthase (TS), an enzyme critical for DNA synthesis. By inhibiting TS, FdUMP helps researchers understand the mechanisms of action of various anti-cancer drugs and develop new therapeutic strategies.
Used in Cancer Therapeutics:
5-Fluoro-2'-deoxyuridine 5'-monophosphate sodium salt has been used as an anti-mitotic agent, targeting rapidly dividing cells such as cancer cells. Its ability to inhibit thymidylate synthase makes it a valuable tool in the development of cancer treatments, particularly for solid tumors.
Biochem/physiol Actions
5-Fluoro-2′-deoxyuridine 5′-monophosphate sodium salt (FdUMP) is an DNA synthesis inhibitor. FdUMP along with RNA synthesis inhibitor 3′-C-ethinylcytidine induces cell death in cervical cancer cells at nanomolar concentrations.
Check Digit Verification of cas no
The CAS Registry Mumber 103226-10-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,3,2,2 and 6 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 103226-10:
(8*1)+(7*0)+(6*3)+(5*2)+(4*2)+(3*6)+(2*1)+(1*0)=64
64 % 10 = 4
So 103226-10-4 is a valid CAS Registry Number.
