1032287-35-6Relevant academic research and scientific papers
A highly enantioselective [4+2] cycloaddition involving aldehydes and β,γ-unsaturated-α-keto esters
Katakam, Nanda Kumar,Kim, Yejin,Headley, Allan D.
, p. 1591 - 1595 (2017)
A stereoselective inverse electron demand oxo-Diels-Alder reaction involving electron poor dienes (γ-aryl-β,γ-unsaturated-α-keto ester) and electron rich dienophiles has been studied. These cycloaddition reactions are extremely useful for the construction of O-, N-, S-centered heterocyclic compounds, which are routinely used in both synthetic organic and medicinal chemistry. The [4+2] hetero cycloaddition reactions involving various aldehydes and β,γ-unsaturated-α-keto esters were carried out in which three different types of substituted proline catalysts were examined. For these reactions, high selectivities (enantiomeric excess 93–98%) were obtained using catalyst 3. Due to the bulkiness of catalyst 3, compared to the other catalysts tested, it is more efficient at catalyzing these type reactions.
Highly enantioselective inverse-electron-demand hetero-diels-alder reactions catalyzed by modularly designed organocatalysts
Sinha, Debarshi,Perera, Sandun,Zhao, John Cong-Gui
, p. 6976 - 6979 (2013/07/28)
MDO rocks! Proline and (2S,3aS,7aS)-octahydro-1H-indole-2-carboxylic acid are both poor catalysts for the inverse-electron-demand hetero-Diels-Alder reactions between aldehydes and electron-deficient enones. However, forming modularly designed organocatal
Enantioselective assembly of substituted dihydropyrones via organocatalytic reaction in water media
Wang, Jing,Yu, Fang,Zhang, Xiaojing,Ma, Dawei
supporting information; experimental part, p. 2561 - 2564 (2009/05/30)
(Chemical Equation Presented) The diarylprolinol ether/HOAc-catalyzed cascade Michael addition and cyclization of aldehydes and α-keto-α, β-unsaturated esters proceeds smoothly in water to afford cyclic hemiacetals, which are oxidized to furnish highly fu
