1032340-41-2Relevant academic research and scientific papers
Synthesis of eudistomin D analogues and its effects on adenosine receptors
Ishiyama, Haruaki,Ohshita, Kengo,Abe, Tetsuro,Nakata, Hiroyasu,Kobayashi, Jun'ichi
, p. 3825 - 3830 (2008)
Six analogues (1-6) of eudistomin D, a β-carboline alkaloid from a marine tunicate Eudistoma olivaceum, were synthesized, and their affinity and selectivity for adenosine receptors A1, A2A, and A3 were examined. All the synthetic compounds 1-6 did not show affinity to the adenosine A1 receptor. δ-Carboline 3 exhibited the most potent affinity to the adenosine receptor A3 among compounds 1-6. δ-Carbolines 3 and 4 showed better affinity than the corresponding β-carbolines 1 and 2, respectively, while N-methylation (2, 4, and 6, respectively) of the pyrrole ring in 1, 3, and 5 resulted in the reduced affinity to the adenosin A3 receptor. On the other hand, an eudistomin D derivative, BED, exhibited modest affinity to all the receptors A1, A2A, and A3 but no selectivity.
