103239-24-3

Basic information

• Product Name: GLUTATHIONE DISODIUM SALT OXIDIZED FORM
• Synonyms: N00677819 [GAMMA-GLU-CYS-GLY] [GAMMA-GLU-CYS-GLY] DISODIUM SALT;GSSG , OXIDIZED FORM DISODIUM SALT;GSSG DISODIUM SALT;GLUTATHIONE, OXIDIZED FORM DISODIUM SALT;GLUTATHIONE DISODIUM SALT OXIDIZED FORM;GLUTATHIONE OXIDIZED DISODIUM SALT;L-GLUTATHIONE OXIDIZED DISODIUM SALT;GLUTATHIONE DISODIUM OXIDIZED FORM*CELL CULTURE TES
• CAS NO: 103239-24-3
• Molecular Formula: C₂₀H₃₂N₆O₁₂S₂*Na
• Molecular Weight: 656.59
• Mol File: 103239-24-3.mol
• Article Data: 1

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: white/powder
• Density: g/cm³
• Storage Temp.: −20°C
• Solubility: H2O: 50 mg/mL, clear, colorless
• BRN: 6265389
• CAS DataBase Reference: GLUTATHIONE DISODIUM SALT OXIDIZED FORM(CAS DataBase Reference)
• NIST Chemistry Reference: GLUTATHIONE DISODIUM SALT OXIDIZED FORM(103239-24-3)
• EPA Substance Registry System: GLUTATHIONE DISODIUM SALT OXIDIZED FORM(103239-24-3)

Safety Data

• WGK Germany: 3
• F: 3
• Hazardous Substances Data: 103239-24-3(Hazardous Substances Data)

Usage

Uses

L-Glutathione Oxidized Disodium is used in cellular redox pathways as a therapeutic target in the treatment of cancer.

InChI:InChI=1/C20H32N6O12S2.2Na/c21-9(19(35)36)1-3-13(27)25-11(17(33)23-5-15(29)30)7-39-40-8-12(18(34)24-6-16(31)32)26-14(28)4-2-10(22)20(37)38;;/h9-12H,1-8,21-22H2,(H,23,33)(H,24,34)(H,25,27)(H,26,28)(H,29,30)(H,31,32)(H,35,36)(H,37,38);;/q;2*+1/p-2/t9-,10-,11+,12+;;/m0../s1

Upstream product

• 70-18-8 GLUTATHIONE 

Relevant articles and documents

Formation of Reducing Radicals on Radiolysis of Glutathione and Some Related Compounds in Aqueous Solution

The .OH-induced oxidation of glutathione in basic aqueous solution has been found to produce the sulphur-centred radical GS. (GSSG.- and two reducing radicals.Decarboxylation, considered to be initiated by .OH radical addition to the nitrogen of the amino group on the γ-glutamyl unit, was found to be effective for methylated glutathione (GSMe) and ophthalmic acid (GMe) but of minor importance for glutathione.The G-values for the strongly reducing α-amino radicals formed on decarboxylation were found to be 3.3, 3.3, and 0.5 for GSMe, GME, and GSH, respectively, at pH 10.5.The formation of an additional strongly reducing radical with G=2.2 at pH 10.5 was demonstrated by measuring the electron-transfer to p-nitroacetophenone (PNAP).This radical is not formed from GSMe or GMe.We suggest that the underlying mechanism for the formation of this species is based on pH-dependent conformational changes of glutathione followed by .OH addition to the cysteine sulphur, or hydrogen abstraction from the CH2 group in the α-position to the sulphur leading to the formation of a reducing carbon-centred radical.