1032401-24-3Relevant academic research and scientific papers
Synthesis of dehydro-β-amino esters via highly regioselective amination of allylic carbonates
Benfatti, Fides,Cardillo, Giuliana,Gentilucci, Luca,Mosconi, Elisa,Tolomelli, Alessandra
supporting information; experimental part, p. 2425 - 2428 (2009/05/26)
(Chemical Equation Presented) The allylic amination of acetates and carbonates affords dehydro-β-aminoesters, which are useful precursors of biologically active compounds. The uncatalyzed reaction proceeds via a S N2′ mechanism. On the other hand, under palladium-catalyzed conditions, the reaction shows a strong solvent-dependent regiocontrol, affording exclusively one of the two possible regioisomers with complete transfer of chirality from the substrates to the products.
