103263-85-0

Basic information

• Product Name: 2-(2,6-DICHLORO-PHENYL)-THIAZOLIDINE-4-CARBOXYLIC ACID
• Synonyms: 2-(2,6-DICHLORO-PHENYL)-THIAZOLIDINE-4-CARBOXYLIC ACID
• CAS NO: 103263-85-0
• Molecular Formula: C₁₀H₉Cl₂NO₂S
• Molecular Weight: 278.15496
• Mol File: 103263-85-0.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Refractive Index: 1.63
• CAS DataBase Reference: 2-(2,6-DICHLORO-PHENYL)-THIAZOLIDINE-4-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2,6-DICHLORO-PHENYL)-THIAZOLIDINE-4-CARBOXYLIC ACID(103263-85-0)
• EPA Substance Registry System: 2-(2,6-DICHLORO-PHENYL)-THIAZOLIDINE-4-CARBOXYLIC ACID(103263-85-0)

Safety Data

• Hazardous Substances Data: 103263-85-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H9Cl2NO2S/c11-5-2-1-3-6(12)8(5)9-13-7(4-16-9)10(14)15/h1-3,7,9,13H,4H2,(H,14,15)/t7-,9?/m1/s1

Upstream product

• 52-90-4 L-Cysteine 
• 83-38-5 2,6-dichlorobenzaldehyde 

Relevant articles and documents

Design, synthesis of 4-aminoquinoline-derived thiazolidines and their antimalarial activity and heme polymerization inhibition studies

The present study describes the synthesis of a series of new 4-aminoquinoline-derived thiazolidines and evaluation of their antimalarial activity against a NF-54 strain of Plasmodium falciparum in vitro and N-67 strain of Plasmodium yoelii in vivo. Among the series, two compounds, 2-(4-chloro-phenyl)-thiazolidine-4-carboxylic acid [2-(7-chloro-quinolin-4- ylamino)-ethyl]-amide hydrochloride (14) and 2-(2,6-dichloro-phenyl)- thiazolidine-4-carboxylic acid [2-(7-chloro-quinolin-4-ylamino)-ethyl]-amide hydrochloride (22) exhibited significant suppression of parasitaemia in the in vivo assay. All the analogues were found to form strong complex with haematin and inhibited the β-haematin formation in vitro. These results suggest that these compounds act on heme polymerization target.