1032764-58-1

Basic information

• Product Name: dimethyl (2S,4S)-4-(2,3-dimethyl-5-oxo-1-phenyl-3-pyrazolin-4-yl)amino-N-phthaloylglutamate
• CAS NO: 1032764-58-1
• Molecular Weight: 506.515
• Mol File: 1032764-58-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: dimethyl (2S,4S)-4-(2,3-dimethyl-5-oxo-1-phenyl-3-pyrazolin-4-yl)amino-N-phthaloylglutamate(CAS DataBase Reference)
• NIST Chemistry Reference: dimethyl (2S,4S)-4-(2,3-dimethyl-5-oxo-1-phenyl-3-pyrazolin-4-yl)amino-N-phthaloylglutamate(1032764-58-1)
• EPA Substance Registry System: dimethyl (2S,4S)-4-(2,3-dimethyl-5-oxo-1-phenyl-3-pyrazolin-4-yl)amino-N-phthaloylglutamate(1032764-58-1)

Safety Data

• Hazardous Substances Data: 1032764-58-1(Hazardous Substances Data)

Upstream product

• 83-07-8 4-amino-2,3-dimethyl-1-phenylpyrazolin-5-one 
• 198133-06-1 Dimethyl ester of 4-bromo-N-phthalyl-L-glutamic acid 

Downstream Products

• 1032764-59-2 (2S,4S)-4-amino-1-(2,3-dimethyl-5-oxo-1-phenyl-3-pyrazolin-4-yl)-5-oxoproline 

Relevant articles and documents

Synthesis and Study of Psychotropic Activity of 1-Substituted 4-Amino-5-oxoprolines

Abstract: 1-Substituted (2S,4S)-4-amino-5-oxoprolines have been obtained by nucleophilic substitution of bromine in dimethyl (2S,4RS)-4-bromo-N-phthaloylglutamate followed by isolation of the predominant (2S,4S)-diastereomer and removal of protecting groups. The psychotropic activity of the obtained compounds has been studied after a single administration in experimental animals. 4-Amino-1-(4-bromophenyl)-5-oxoproline and especially 4-amino-1-(4-aminophenyl)-5-oxoproline showed pronounced anxiolytic activity in the Elevated plus maze test. (2S,4S)-4-Amino-5-oxoprolines containing 4-methylphenyl, 4-bromophenyl, 4?aminophenyl, and 2,3-dimethyl-5-oxo-1-phenyl-3-pyrazolin-4-yl substituents at the 1-position exhibited nootropic activity: they improved the formation and retention of the memory trace in the Passive avoidance test and the Active avoidance test (Extrapolation escape test).