1032767-72-8

Basic information

• Product Name: (2R)-2-[[(1S)-1-tert-butoxycarbonyl-5-(tert-butoxycarbonylamino)pentyl]carbamoylamino]-3-cyclohexylpropanoic acid
• Synonyms: (2R)-2-[[(1S)-1-tert-butoxycarbonyl-5-(tert-butoxycarbonylamino)pentyl]carbamoylamino]-3-cyclohexylpropanoic acid
• CAS NO: 1032767-72-8
• Molecular Weight: 499.648
• Mol File: 1032767-72-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (2R)-2-[[(1S)-1-tert-butoxycarbonyl-5-(tert-butoxycarbonylamino)pentyl]carbamoylamino]-3-cyclohexylpropanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (2R)-2-[[(1S)-1-tert-butoxycarbonyl-5-(tert-butoxycarbonylamino)pentyl]carbamoylamino]-3-cyclohexylpropanoic acid(1032767-72-8)
• EPA Substance Registry System: (2R)-2-[[(1S)-1-tert-butoxycarbonyl-5-(tert-butoxycarbonylamino)pentyl]carbamoylamino]-3-cyclohexylpropanoic acid(1032767-72-8)

Safety Data

• Hazardous Substances Data: 1032767-72-8(Hazardous Substances Data)

Upstream product

• 1032767-71-7 (R)-2-amino-3-cyclohexylpropanoic acid trifluoroacetate 
• 13288-57-8 1,1-dimethylethyl N₆-{[(1,1-dimethylethyl)oxy]carbonyl}-L-lysinate hydrochloride 
• 127095-92-5 N-tert-butoxycarbonyl-D-cyclohexylalanine 
• 530-62-1 1,1'-carbonyldiimidazole 

Downstream Products

• 1032765-93-7 (2S)-2-[[(1R)-2-(2-adamantylamino)-1-(cyclohexylmethyl)-2-oxo-ethyl]carbamoylamino]-6-aminohexanoic acid trifluoroacetate 
• 1032766-17-8 (2S)-6-amino-2-[[(1R)-1-(cyclohexylmethyl)-2-oxo-2-pyrrolidin-1-ylethyl]carbamoylamino]hexanoic acid trifluoroacetate 
• 1032765-97-1 (2S)-6-amino-2-[[(1R)-1-(cyclohexylmethyl)-2-(isobutylamino)-2-oxoethyl]carbamoylamino]hexanoic acid trifluoroacetate 
• 1032764-89-8 (2S)-6-amino-2-[[(1R)-2-[[(1S)-1-(4-chlorophenyl)ethyl]amino]-1-(cyclohexylmethyl)-2-oxoethyl]carbamoylamino]hexanoic acid trifluoroacetate 
• 1032764-77-4 (2S)-6-amino-2-[[(1R)-2-[(4-chlorophenyl)methylamino]-1-(cyclohexylmethyl)-2-oxoethyl]carbamoylamino]hexanoic acid trifluoroacetate 
• 1032764-91-2 (2S)-6-amino-2-[[(1R)-1-(cyclohexylmethyl)-2-[(4-methoxyphenyl)methylamino]-2-oxoethyl]carbamoylamino]hexanoic acid trifluoroacetate 
• 1032765-03-9 (2S)-6-amino-2-[[(1R)-1-(cyclohexylmethyl)-2-(2,2-diphenylethylamino)-2-oxoethyl]carbamoylamino]hexanoic acid trifluoroacetate 
• 1032765-59-5 (2S)-6-amino-2-[[(1R)-2-[[(1S)-1-cyclohexylethyl]amino]-1-(cyclohexylmethyl)-2-oxoethyl]carbamoylamino]hexanoic acid trifluoroacetate 
• 1032765-53-9 (2S)-6-amino-2-[[(1R)-1-(cyclohexylmethyl)-2-[[(1R)-1,2-dimethylpropyl]amino]-2-oxoethyl]carbamoylamino]hexanoic acid trifluoroacetate 
• 1032765-05-1 (2S)-6-amino-2-[[(1R)-1-(cyclohexylmethyl)-2-(2,2-dimethylpropylamino)-2-oxoethyl]carbamoylamino]hexanoic acid trifluoroacetate 

Relevant articles and documents

Novel Small Molecule Inhibitors of Activated Thrombin Activatable Fibrinolysis Inhibitor (TAFIa) from Natural Product Anabaenopeptin

Anabaenopeptins isolated from cyanobacteria were identified as inhibitors of carboxypeptidase TAFIa. Cocrystal structures of these macrocyclic natural product inhibitors in a modified porcine carboxypeptidase B revealed their binding mode and provided the basis for the rational design of small molecule inhibitors with a previously unknown central urea motif. Optimization based on these design concepts allowed for a rapid evaluation of the SAR and delivered potent small molecule inhibitors of TAFIa with a promising overall profile.