103281-01-2Relevant academic research and scientific papers
Antibacterial, antioxidant and binding studies of some novel diaryl sulphide derivatives
Moosun, Salma,Bhowon, Minu G.,Jhaumeer-Laulloo, Sabina,Joule, John A.
, p. 1383 - 1400,18 (2020/08/31)
A series of novel acyclic and cyclic diaryl sulphides was synthesized from 2,2-dithiobenzoic acid. The various diaryl sulphides were characterized by use of spectral (IR, 1H and 13C NMR, ESI/MS) and elemental analyses. The antimicrobial activities of the compounds were evaluated in terms of their minimum inhibition concentration (MIC) against a panel of clinical isolates bacteria and were found to possess only moderate antimicrobial activities. N,N-Bis(2-hydroxyphenyl)-2,2-thiodibenzamide (13), exhibiting a hydroxy group at the phenyl ring, was the most active antimicrobial agent within the series, with MIC values of 0.05 mg mL-1 and 10 mg mL -1 against Staphylococcus aureus and Bacillus cereus, respectively. The antioxidant efficiency of the diaryl sulphides was determined by 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity with 13 being the most active compound. The interaction of 2,2-thiodibenzanilide, N,N-bis(2- methylphenyl)-2,2-thiodibenzamide, and N,N-bis(2-hydroxyphenyl)-2,2- thiobenzamide with guanine, glutamic acid, and urea were studied quantitatively with binding constants ranging from 1 × 103 M1 to 2.7 × 104 M1.
