1032816-26-4

Basic information

• Product Name: C₃₆H₄₀ClN₃O₄
• CAS NO: 1032816-26-4
• Molecular Weight: 614.184
• Mol File: 1032816-26-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₃₆H₄₀ClN₃O₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₆H₄₀ClN₃O₄(1032816-26-4)
• EPA Substance Registry System: C₃₆H₄₀ClN₃O₄(1032816-26-4)

Safety Data

• Hazardous Substances Data: 1032816-26-4(Hazardous Substances Data)

Upstream product

• 135050-44-1 3-chloro-4-iodoaniline 
• 172975-69-8 3,5-dimethylphenyl boronic acid 
• 1021913-05-2 tert-butyl (2R)-2-{2-[(3-bromo-7-chloro-6-iodoquinolin-4-yl)oxy]ethyl}piperidine-1-carboxylate 
• 1021913-04-1 3-bromo-7-chloro-6-iodoquinolin-4-ol 
• 1021913-03-0 7-chloro-6-iodoquinolin-4-ol 
• 1021913-07-4 7-chloro-4-hydroxy-6-iodoquinoline-3-carboxylic acid 
• 1021913-01-8 ethyl 7-chloro-4-hydroxy-6-iodoquinoline-3-carboxylate 
• 1021912-99-1 diethyl {[(3-chloro-4-iodophenyl)amino]methylidene}propanedioate 

Downstream Products

• 1021911-30-7 3-{7-chloro-3-(3,5-dimethylphenyl)-4-[2-(piperidin-2-yl)ethoxy]quinolin-6-yl}benzamide 

Relevant articles and documents

Design, synthesis, and evaluation of novel 3,6-diaryl-4- aminoalkoxyquinolines as selective agonists of somatostatin receptor subtype 2

Agonists of somatostatin receptor subtype 2 (sst2) have been proposed as therapeutics for the treatment of proliferative diabetic retinopathy and exudative age-related macular degeneration. An HTS screen identified 2-quinolones as weak agonists of sst2, and these were optimized to provide small molecules with sst2 binding and functional potency comparable to peptide agonists. Agonist 21 was shown to inhibit rat growth hormone secretion following systemic administration and to inhibit ocular neovascular lesion formation after local administration.