1032826-73-5

Basic information

• Product Name: [5-amino-1-(4-fluorophenyl)-1H-pyrazol-4-yl][3-(1,4-dioxaspiro[4.5]dec-8-yloxy)phenyl]methanone
• Synonyms: [5-amino-1-(4-fluorophenyl)-1H-pyrazol-4-yl][3-(1,4-dioxaspiro[4.5]dec-8-yloxy)phenyl]methanone
• CAS NO: 1032826-73-5
• Molecular Weight: 437.471
• Mol File: 1032826-73-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: [5-amino-1-(4-fluorophenyl)-1H-pyrazol-4-yl][3-(1,4-dioxaspiro[4.5]dec-8-yloxy)phenyl]methanone(CAS DataBase Reference)
• NIST Chemistry Reference: [5-amino-1-(4-fluorophenyl)-1H-pyrazol-4-yl][3-(1,4-dioxaspiro[4.5]dec-8-yloxy)phenyl]methanone(1032826-73-5)
• EPA Substance Registry System: [5-amino-1-(4-fluorophenyl)-1H-pyrazol-4-yl][3-(1,4-dioxaspiro[4.5]dec-8-yloxy)phenyl]methanone(1032826-73-5)

Safety Data

• Hazardous Substances Data: 1032826-73-5(Hazardous Substances Data)

Upstream product

• 249937-13-1 [5-amino-1-(4-fluorophenyl)-1H-pyrazol-4-yl]-(3-hydroxyphenyl)methanone 
• 23511-05-9 toluene-4-sulfonic acid 1,4-dioxa-spiro[4.5]dec-8-yl ester 

Downstream Products

• 1032826-74-6 4-(3-{[5-amino-1-(4-fluorophenyl)-1H-pyrazol-4-yl]carbonyl}phenoxy)-cyclohexanone 

Relevant articles and documents

2-(HETERO-)ARYL,4-CARBONYL SUBSTITUTED PYRAZOLE DERIVATIVES AS INHIBITORS OF P38 MITOGEN-ACTIVATED PROTEIN KINASE

Compounds of formula (I) are inhibitors of p38 MAP kinase activity, and are useful in the treatment of, inter alia, inflammatory and autoimmune disease wherein Ring A is aryl, heteroaryl or heterocyclyl of 5-13 atoms; Ring B is optionally substituted aryl or heteroaryl of 5-13 atoms; Z is (a) a radical of formula -(CH2)z-X1-L1-Y- NHCHR1R2 or (b) a radical of formula -(CH2)z-Y1-L1-R wherein R1R2CHNH- and R are respectively N- and C-linked amino acid or amino acid ester groups as defined in the description, and -Y-L1-X1-(CH2)z- and -L1-Y1-(CH2)z- are linker radicals as defined in the description; R7 is hydrogen or -C(=O)R' where R' is hydrogen, (C1-C6)alkyl, (C3-C6)cycloalkyl or (C1-C6)haloalkyl; R8 is hydrogen or (C1C6)alkyl; R9 is hydrogen, halogen, hydroxyl, (C1-C6)alkoxy, (C1-C6)alkyl; R18 is hydrogen, halogen, hydroxyl, (C1C6)alkoxy (C1-C6)alkyl, - NRaRb where Ra and Rb are hydrogen or (C1-C6)alkyl, or optionally substituted aryl, heteroaryl or heterocyclyl or Ra and Rb when taken together with the nitrogen to which they are attached form a cyclic amino group of up to 6 ring atoms; R19 is hydrogen, halogen, (C1C6)alkoxy, or (C1C6)alkyl.