1032903-62-0

Basic information

• Product Name: 4-(5-isopropoxy-2-Methyl-4-nitrophenyl)pyridine
• Synonyms: 4-(5-isopropoxy-2-Methyl-4-nitrophenyl)pyridine;EOS-60653;4-(2-methyl-4-nitro-5-propan-2-yloxyphenyl)pyridine
• CAS NO: 1032903-62-0
• Molecular Formula: C₁₅H₁₆N₂O₃
• Molecular Weight: 272.29914
• Mol File: 1032903-62-0.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 404.2±40.0 °C(Predicted)
• Appearance: /
• Density: 1.166±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.61±0.10(Predicted)
• CAS DataBase Reference: 4-(5-isopropoxy-2-Methyl-4-nitrophenyl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(5-isopropoxy-2-Methyl-4-nitrophenyl)pyridine(1032903-62-0)
• EPA Substance Registry System: 4-(5-isopropoxy-2-Methyl-4-nitrophenyl)pyridine(1032903-62-0)

Safety Data

• Hazardous Substances Data: 1032903-62-0(Hazardous Substances Data)

Usage

General Description

4-(5-isopropoxy-2-methyl-4-nitrophenyl)pyridine is a complex organic compound comprising of various functional groups. Notable components of its chemical structure include a pyridine ring, a nitrophenyl group, and an isopropoxy group. The pyridine ring is a simple aromatic ring with one nitrogen atom, while the nitrophenyl group, is characterized by a nitro (NO2) group attached to a phenyl ring. Alongside, an isopropoxy group, an alkyl ether, is also present in this compound. It contains an isopropyl group bonded to an oxygen atom. The exact properties such as melting point, boiling point, density, among others would depend on its precise molecular configuration, purity, and conditions. It's use and application would primarily depend on these chemical properties. Currently, there is limited data available on this particular chemical's use or hazards. It's vital to handle all such chemicals safely and with appropriate protective equipment, given the potential risks associated with exposure.

Upstream product

• 1032903-50-6 1-chloro-2-methyl-4-nitro-5-(propan-2-yloxy)benzene 
• 19524-06-2 4-bromopyridine hydrochloride 
• 73183-34-3 bis(pinacol)diborane 
• 1202858-68-1 1-bromo-5-isopropoxy-2-methyl-4-nitrobenzene 
• 1692-15-5 4-pyridylboronic acid 
• 64695-96-1 1-bromo-5-fluoro-2-methyl-4-nitrobenzene 
• 1422-53-3 2-bromo-4-fluorotoluene 
• 452-73-3 2-chloro-4-fluorotoluene 
• 112108-73-3 1-chloro-5-fluoro-2-methyl-4-nitrobenzene 

Downstream Products

• 1032903-65-3 4-(5-isopropoxy-2-methyl-4-nitrophenyl)-1-methyl-pyridinium iodide 
• 1035230-24-0 5-chloro-N²-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N⁴-((2-isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine 
• 1032903-63-1 4-(4-amino-5-isopropoxy-2-methylphenyl)-piperidine-1-carboxylic acid tert-butyl ester 
• 1032903-66-4 2-isopropoxy-5-methyl-4-(1-methyl-piperidin-4-yl)-phenylamine 
• 1380575-43-8 5-chloro-N²-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N⁴-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine hydrochloride 
• 1445894-96-1 N₂-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N₄-(2-(isopropylsulfonyl)phenyl)-5-methylpyrimidine-2,4-diamine 
• 1445894-97-2 5-chloro-N₄-(2-(cyclobutylsulfonyl)phenyl)-N₂-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)pyrimidine-2,4-diamine 
• 1445895-03-3 5-chloro-N₂-(2-isopropoxy-5-methyl-4-(1-ethylpiperidin-4-yl)phenyl)-N₄-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine 
• 1445895-04-4 5-chloro-N₂-(2-isopropoxy-5-methyl-4-(1-isopropylpiperidin-4-yl)phenyl)-N₄-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine 
• 1445895-08-8 5-chloro-N₂-(4-(1-(2,2-difluoroethyl)piperidin-4-yl)-2-isopropoxy-5-methylphenyl)-N₄-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine 
• 1190399-47-3 1-(4-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidin-1-yl)-2-(dimethylamino)ethanone 
• 1445895-25-9 2-(4-(5-isopropoxy-4-((4-((2-(isopropylsulfonyl)phenyl)amino)-5-methylpyrimidin-2-yl)amino)-2-methylphenyl)piperidin-1-yl)ethanol 
• 1445895-27-1 N₂-(2-isopropoxy-4-(1-(2-methoxyethyl)piperidin-4-yl)-5-methylphenyl)-N₄-(2-(isopropylsulfonyl)phenyl)-5-methylpyrimidine-2,4-diamine 
• 1445894-99-4 4-bromo-5-chloro-N-(2-isopropoxy-5-methyl-4-(1-methylpiperidin-4-yl)phenyl)pyridin-2-amine 

Relevant articles and documents

CHEMICAL PROCESS FOR PREPARING PYRIMIDINE DERIVATIVES AND INTERMEDIATES THEREOF

PROBLEM TO BE SOLVED: To provide a process for preparing ceritinib and/or intermediates thereof. SOLUTION: There is provided a process for preparing (C2-1), an intermediate of ceritinib synthesis, comprising the step of reacting (A) with (B) in a solvent in the presence of at least one catalyst, wherein P is a protecting group and T and X1 independently denote Cl and the like. SELECTED DRAWING: None COPYRIGHT: (C)2021,JPOandINPIT

Chemical Process for Preparing Pyrimidine Derivatives and Intermediates Thereof

The present disclosure relates to a method of synthesizing 5-chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-[2-(propane-2-sulfonyl)-phenyl]-pyrimidine-2,4-diamine (ceritinib) and/or intermediates thereof, their use as pharmaceuticals and pharmaceutical compositions and the use of intermediates for preparing ceritinib.

HYDRATE OF 2-ISOPROPOXY-5-METHYL-4-(PIPERIDIN-4-YL) ANILINE DIHYDROCHLORIDE, PREPARATION METHOD AND USE OF THE SAME

The present invention relates to 2-isopropoxy-5-methyl-4-(piperidin-4-yl) aniline dihydrochloride monohydrate and a preparation method of the same. The 2-isopropoxy-5-methyl-4-(piperidin-4-yl) aniline dihydrochloride monohydrate has a very good crystal form and is well suitable for recrystallization purification; further, the effect of impurity removal effect is very good, and any single impurity can be controlled less than 0.1%.