103292-14-4

Upstream product

• 103292-13-3 4-Formyl-3-hydroxyphenyl 2,3,4,6-tetra-O-acetyl-β-D-galactopyranoside 
• 74-88-4 methyl iodide 
• 18278-34-7 4-hydroxy-2-methoxybenzaldehyde 
• 572-09-8 2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide 
• 95-01-2 2,4-Dihydroxybenzaldehyde 
• 103292-13-3 [(2R,3R,4S,5R,6S)-3,4,5-tris(acetyloxy)-6-(4-formyl-3-hydroxyphenoxy)oxan-2-yl]methyl acetate 
• 19186-59-5 2,3,4,6-tetra-O-acetyl-α-D-galactopyranosyl bromide 

Downstream Products

• 103292-15-5 4-Formyl-3-methoxyphenyl β-D-galactopyranoside 
• 103292-16-6 3-Methoxy-4-(2-nitrovinyl)phenyl β-D-glucopyranoside 
• 103292-16-6 3-Methoxy-4-(2-nitrovinyl)phenyl β-D-galactopyranoside 

Relevant academic research and scientific papers

NOVEL PYRAZOLE DERIVATIVE

Provided is a novel therapeutic means for Alzheimer's disease. In particular, provided is a compound represented by the following general formula (I): [wherein Ar1 represents 2-methoxy-4-(2-pyridylmethoxy)phenyl etc. and Ar2 represents a 1H-indol-6-yl group etc.] or a salt thereof.

3-Methoxy-4-(2-nitrovinyl)phenyl glycosides as potential chromogenic substrates for the assay of glycosidases.

Selective glycosidation of 2,4-dihydroxybenzaldehyde with either 2,3,4, 6-tetra-O-acetyl-alpha-D-glucopyranosyl bromide, 2-acetamido-3,4,6-tri-O-acetyl-alpha-D-glucopyranosyl chloride, or 2,3,4,6-tetra-O-acetyl-alpha-D-galactopyranosyl bromide afforded the corresponding 4-O-glycosyl derivatives. Subsequent O-methylation, O-deacetylation, and condensation with nitromethane afforded the appropriate beta-glycoside of 3-methoxy-4-(2-nitrovinyl)phenol. The phenol is highly coloured at alkaline pH so that these glycosides may be suitable as chromogenic substrates for the assay of glycosidases.