103294-01-5

Upstream product

• 99-61-6 3-nitro-benzaldehyde 
• 2996-92-1 phenyl trimethylsiloxane 
• 141-97-9 ethyl acetoacetate 
• 39562-16-8 ethyl 2-(3-nitrophenylmethylene)-3-oxobutanoate 
• 143996-69-4 6-Methyl-4-(3-nitro-phenyl)-2-phenyl-1,4-dihydro-pyrimidine-5-carboxylic acid ethyl ester 

Downstream Products

• 103293-97-6 5-tert-Butyloxycarbonylamino-6-methyl-4-(3-nitrophenyl)-2-phenylpyrimidine 
• 103293-98-7 5-Amino-6-methyl-4-(3-nitrophenyl)-2-phenylpyrimidine 
• 103293-99-8 N-(2-dimethylaminoethyl)-6-methyl-4-(3-nitrophenyl)-2-phenyl-5-pyrimidinecarboxamide 
• 103294-21-9 6-methyl-5-(4-methylpiperazin-1-ylcarbonyl)-4-(3-nitrophenyl)-2-phenylpyrimidine 
• 103293-96-5 6-methyl-4-(3-nitrophenyl)-2-phenyl-5-pyrimidinecarboxylic acid 

Relevant academic research and scientific papers

Palladium-Catalyzed Copper-Promoted Hiyama-Type Carbon-Carbon Cross-Coupling Reactions of Dihetaryl Disulfides as Electrophiles

Dihetaryl disulfides were used as electrophiles in a palladium-catalyzed carbon-carbon cross-coupling reaction with arylsilanes to realize a Hiyama-type reaction. This unique transformation shows high reactivity, excellent functional-group tolerance, and mild reaction conditions, making it an attractive alternative to conventional cross-coupling approaches for carbon-carbon bond construction.

Studies on cerebral protective agents. II. Novel 4-arylpyrimidine derivatives with anti-anoxic and anti-lipid peroxidation activities.

In a search for new cerebral protective agents with anti-anoxic (AA) and anti-lipid peroxidation (ALP) activities, a series of 4-arylpyrimidines, bearing an amino moiety in the C-5 position of the pyrimidine nucleus, was synthesized and tested for AA and

Studies on cerebral protective agents. I. Novel 4-arylpyrimidine derivatives with anti-anoxic and anti-lipid peroxidation activities

Novel 4-arylpyrimidine derivatives were synthesized by the oxidation of 4-aryl-1,4-dihydropyrimidines, and their effects on anti-anoxic (AA) activity in mice and anti-lipid peroxidation (ALP) activity in rat brain mitochondria were investigated. Among these compounds, ethyl 6-methyl-2-phenyl-4-(4-pyridyl)-5-pyrimidinecarboxylate (4b) has AA activity (10mg/kg, i.p.) and ethyl 6-methyl-4-(3-nitrophenyl)-2-phenyl-5-pyrimidinecarboxylate (4f) has ALP activity (73% inhibition at 10-5 g/ml). The latter compound (100mg/kg, i.p.) was also effective on arachidonate-induced cerebral edema in rats with comparable potency to that of vitamin E.

Pyrimidine derivatives, processes for preparation thereof and composition containing the same

The invention relates to pyrimidine derivatives and their pharmaceutically acceptable salts which are useful in the treatment of cerebrovascular diseases, to processes for preparation thereof and to the composition containing the same, said pyrimidine der