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CAS

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103297-90-1

3-(4-methoxybenzyl)-1-(4-nitrophenyl)-3-azabicyclo[3.1.1]heptane-2,4-dione is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 103297-90-1 Structure

  • Basic information

    1. Product Name: 3-(4-methoxybenzyl)-1-(4-nitrophenyl)-3-azabicyclo[3.1.1]heptane-2,4-dione
    2. Synonyms: 3-(4-methoxybenzyl)-1-(4-nitrophenyl)-3-azabicyclo[3.1.1]heptane-2,4-dione
    3. CAS NO:103297-90-1
    4. Molecular Formula:
    5. Molecular Weight: 366.373
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 103297-90-1.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 3-(4-methoxybenzyl)-1-(4-nitrophenyl)-3-azabicyclo[3.1.1]heptane-2,4-dione(CAS DataBase Reference)
    10. NIST Chemistry Reference: 3-(4-methoxybenzyl)-1-(4-nitrophenyl)-3-azabicyclo[3.1.1]heptane-2,4-dione(103297-90-1)
    11. EPA Substance Registry System: 3-(4-methoxybenzyl)-1-(4-nitrophenyl)-3-azabicyclo[3.1.1]heptane-2,4-dione(103297-90-1)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 103297-90-1(Hazardous Substances Data)

103297-90-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 103297-90-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,3,2,9 and 7 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 103297-90:
(8*1)+(7*0)+(6*3)+(5*2)+(4*9)+(3*7)+(2*9)+(1*0)=111
111 % 10 = 1
So 103297-90-1 is a valid CAS Registry Number.

103297-90-1Relevant articles and documents

Synthesis and aromatase inhibitory activity of novel 1-(4-aminophenyl)-3-azabicyclo[3.1.0[hexane- and -[3.1.1]heptane-2,4- diones

Stanek,Alder,Bellus,Bhatnagar,Hausler,Schieweck

, p. 1329 - 1334 (2007/10/02)

The synthesis of 3-(cyclohexylmethyl)-1-(4-aminophenyl)-3-azabicyclo [3.1.0]hexane-2,4-dione (1h), with its optical enantiomers, and a series of novel achiral 1-(4-aminophenyl)-3- azabicyclo[3.1.1]haptane-2,4-diones (2a-i,k) is described. These compounds were tested in vitro for inhibition of human placental aromatase, a cytochrome-P450-dependent enzyme responsible for the conversion of androgens to estrogens. All of them displayed enzyme-inhibiting activity, and 3-cyclohexyl derivative 2g and 3-cyclohexylmethyl derivative 1h both proved more potent (>140-fold) than the clinically effective agent aminoglutethimide [3-(4-aminophenyl)- 3-ethylpiperidine-2,6-dione, AG]. As with AG and its derivatives, the 1R-(+)-enantiomer of 1h was responsible for the enzyme inhibitory activity. These novel compounds are of interest as potential drugs for endocrine therapy of hormone-dependent tumors, e.g. breast cancer.

Substituted-3-azabicyclo[3.1.1]heptane-2,4-diones useful for treating hormone-dependent diseases

-

, (2008/06/13)

1-phenyl-3-azabicyclo[3.1.1]-heptane-2,4-diones of the formula STR1 in which R1 represents hydrogen or a saturated or unsaturated, aliphatic, cycloaliphatic, cycloaliphatic-aliphatic, aromatic or aromatic-aliphatic hydrocarbon radical having up

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