103298-41-5

Upstream product

• 38980-93-7 4-(4-nitrophenyl)-1H-imidazole 
• 77-78-1 dimethyl sulfate 
• 64-17-5 ethanol 
• 13707-46-5 N-tosyl-4-nitrobenzaldimine 
• 38622-91-2 [(p-methylphenyl)sulfonylmethyl]isonitrile 
• 7664-93-9 sulfuric acid 
• 74-88-4 methyl iodide 
• 670-95-1 4-Phenylimidazole 
• 555-16-8 4-nitrobenzaldehdye 

Downstream Products

• 89250-16-8 1-methyl-4-(4-aminophenyl)1H-imidazole 
• 89250-48-6 N-cyano-N'-(4-1-methyl-1H-imidazol-4-ylphenyl)formamidine 
• 103298-44-8 N-isopropyl-N'-(4-1-methyl-1H-imidazol-4-ylphenyl)formamidine 

Relevant academic research and scientific papers

HEPARAN SULFATE BIOSYNTHESIS INHIBITORS FOR THE TREATMENT OF DISEASES

Described herein are compounds of Formula I, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or conditions in need of inhibition of heparan sulfate biosynthesis.

NOVEL COMPOUNDS FOR TREATING INFLAMMATORY DISEASES

The invention relates to novel compounds of formula (1), heteroderivatives thereof, and pharmacologically compatible salts, diastereomers, enantiomers, racemates, hydrates or solvates thereof, that are suitable for treating respiratory or gastrointestinal

NOVEL AMIDE COMPOUNDS

A compound of the formula (I):R1-A-X-NHCO-Y-R2 ???whereinR1 is heterocyclic group which may have suitable substituents, or phenyl which may have suitable substituents,R2 is condensed phenyl which may have suitable substituents, phenyl which may have suitable substituents, or thienyl which may have suitable substituents,A is a group of the formula:-(CH2)t-(O)m- or in which R3 and R4 are each hydrogen or linked together to form imino,R5 is hydrogen or lower alkyl,t is 0, 1 or 2,p, m and n are each 0 or 1,X is phenylene which may have suitable substituents, or bivalent heterocyclic group containing nitrogen which may have suitable substituents,Y is bond, lower alkylene, or lower alkenylene, and a salt thereof.

Novel synthesis of 4(5)-monosubstituted imidazoles via cycloaddition of tosylmethyl isocyanide to aldimines

4(5)-Monosubstituted imidazoles (9) have been prepared via base-induced cycloaddition of tosylmethyl isocyanide (TosMIC) to N-(dimethylsulfamoyl)aldimines (2) or N-tosylaldimines (3). In the first case, N-(dimethylsulfamoyl)imidazoles 8 are the initial reaction products, from which the dimethylsulfamoyl group is readily removed with aqueous HBr. In the second case, the tosyl group of 1-tosylimidazoles 10 is lost spontaneously to give 4(5)-monosubstituted imidazoles 9 in one operation.