1033-01-8

Basic information

• Product Name: N-(2,4-Dinitrophenyl)-p-toluidine
• Synonyms: 2,4-Dinitro-4'-methyldiphenylamine;N-(2,4-Dinitrophenyl)-p-toluidine;N-(4-Methylphenyl)-2,4-dinitroaniline;(2,4-Dinitro-phenyl)-p-tolyl-amine
• CAS NO: 1033-01-8
• Molecular Formula: C₁₃H₁₁N₃O₄
• Molecular Weight: 273.2441
• Mol File: 1033-01-8.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 429.4°Cat760mmHg
• Flash Point: 213.5°C
• Appearance: /
• Density: 1.398g/cm³
• Vapor Pressure: 1.41E-07mmHg at 25°C
• Refractive Index: 1.676
• CAS DataBase Reference: N-(2,4-Dinitrophenyl)-p-toluidine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2,4-Dinitrophenyl)-p-toluidine(1033-01-8)
• EPA Substance Registry System: N-(2,4-Dinitrophenyl)-p-toluidine(1033-01-8)

Safety Data

• Hazardous Substances Data: 1033-01-8(Hazardous Substances Data)

Usage

General Description

N-(2,4-Dinitrophenyl)-p-toluidine is a chemical compound commonly used in the field of analytical chemistry as a reagent for detecting the presence of carbonyl compounds. It is often employed in the qualitative analysis of aldehydes and ketones, where it reacts with the carbonyl functional group to produce a highly colored derivative. This derivative can be easily observed and measured, allowing chemists to identify the presence of carbonyl compounds in a sample. The compound is also known for its toxic and irritant properties, and proper safety precautions are necessary when handling and working with it.

InChI:InChI=1/C13H11N3O4/c1-9-2-4-10(5-3-9)14-12-7-6-11(15(17)18)8-13(12)16(19)20/h2-8,14H,1H3

Upstream product

• 977-41-3 2-nitro-benzenesulfonic acid-(2,4-dinitro-phenyl ester) 
• 106-49-0 p-toluidine 
• 70-34-8 2,4-Dinitrofluorobenzene 
• 352-32-9 p-fluorotoluene 
• 97-02-9 2,4-Dinitroanilin 
• 99-65-0 meta-dinitrobenzene 
• 97-00-7 1-chloro-2,4-dinitro-benzene 
• 120952-16-1 2-(2,4-dinitrophenoxy)-N-ethylpyridinium tetraphenylborate 

Downstream Products

• 51117-61-4 (2,4-dinitro-phenyl)-(4-methyl-2-nitro-phenyl)-amine 
• 78316-35-5 4-nitro-N¹-p-tolyl-o-phenylenediamine 
• 14624-91-0 2-methyl-1-p-tolyl-1H-benzoimidazol-5-ylamine 
• 46726-72-1 4'-Methyl-2,4-diamino-diphenylamin 

Relevant articles and documents

Reaction kinetics investigation of 1-fluoro-2,4-dinitrobenzene with substituted anilines in ethyl acetate-methanol mixtures using linear and nonlinear free energy relationships

Aromatic nucleophilic substitution reaction of 1-fluoro-2,4-dinitrobenzene with para-substituted and meta-substituted anilines was kinetically investigated in the mixtures of ethyl acetate and methanol at room temperature. The correlation of second-order rate coefficients with Hammett's substituent constants yields a fairly linear straight line with negative slope in different mole fractions of ethyl acetate-methanol mixtures. The measured rate coefficients of the reaction demonstrated a dramatic variation in ethyl acetate-methanol mixtures with the increasing mole fraction of ethyl acetate. Linear free energy relationship (LFER) investigations confirm that polarity has a major effect on the reaction rate whereas the hydrogen-bonding ability of the media has a slight effect on it. Nonlinear free energy relationship based on preferential solvation hypothesis showed differences between the microsphere solvation of the solute and the bulk composition of the solvents, and non-ideal behavior is observed in the trend of the rate coefficients, which cover the LFER results. Copyright

Effects of the nucleophile structure on the mechanisms of reaction of 1-chloro-2,4-dinitrobenzene with aromatic amines in aprotic solvents

The kinetics of reactions of 1-chloro-2,4-dinitrobenzene with aniline and several substituted aromatic amines, B, in toluene shows a quadratic dependence of the second-order rate constant, kA, on [B], which is preserved even in the presence of increasing amounts of dimethylaniline, while the reaction with N-methylaniline shows a linear dependence of kA vs [B]. All these results are interpreted by the "dimer nucleophile" mechanism, and confirmed by the effects of a non-nucleophilic hydrogen bond acceptor tertiary amine which show the relevance of the structure of the nucleophile and the role of mixed aggregates in defining the mechanisms of aromatic nucleophilic substitutions with amines in aprotic solvents.

Deep eutectic solvent as an operative media on structure-reactivity relationships

Deep eutectic solvents seem to be environmentally friendly solvents, particularly because they are prepared easily and have very low-vapor pressures under ambient conditions. They are suitable candidates as green solvents for reaction media with special properties. To present this behavior, substitution reactions of some para- and meta-substituted anilines with 1-fluoro-2,4-dinitrobenzene have been spectrophotometrically investigated in varying mole fractions of ethaline as a deep eutectic solvent in dimethyl sulfoxide (DMSO). The measured rate coefficients of the reaction demonstrated a noticeable variation with the increasing mole fraction of ethaline in ethaline-DMSO mixtures. The linear free energy relationship (LFER) of second-order rate coefficients based on Hammett's substituent constants demonstrates a reasonably linear straight line with a negative slope in different mole fractions of ethaline-DMSO mixtures. Another LFER investigation based on the polarity parameters of the media showed a good agreement with hydrogen bond donor and acceptor abilities of the solvent. Non-LFER assay according to the preferential solvation model confirmed differences between the microsphere solvation of the solute molecules and the bulk composition of the solvents.