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Usage

Uses

Used in Pharmaceutical Research and Drug Development:
Piperazine, 1-(2-phenylethyl)-4-(2-pyridinyl)is utilized as a compound with potential therapeutic properties for the treatment of various medical conditions. Its unique structure allows it to be a candidate for addressing psychiatric disorders and neurological diseases due to its interaction with specific biological targets.
Used in the Synthesis of Complex Organic Compounds:
In the chemical industry, Piperazine, 1-(2-phenylethyl)-4-(2-pyridinyl)serves as a building block for the synthesis of more complex organic compounds. Its versatile structure enables the creation of a wide range of molecules with diverse applications in various fields, including medicinal chemistry and materials science.

Upstream product

• 34803-66-2 1-(2-pyridyl)piperazine 
• 103-63-9 1-phenyl-2-bromoethane 

Relevant academic research and scientific papers

N-nrylalkylpiperidines as high-affinity sigma-1 and sigma-2 receptor ligands: Phenylpropylamines as potential leads for selective sigma-2 agents

To delineate the differences between the structural requirements necessary for recognition at sigma-1 and sigma-2 receptors, a range of phenethyl- and phenylpropylpiperidines were evaluated in binding assays. Phenethylpiperidines were found to favor sigma-1 receptors, whereas phenylpropylpiperidines tend to favor sigma-2 receptors. It appears that phenylpropylamine is a potential pharmacophore for selective sigma-2 ligands.

New μ-opioid receptor agonists with piperazine moiety

New μ-opioid receptor (MOR) agonists containing piperazine and homopiperazine moieties in the structures were synthesized and their affinities to and agonist potencies on MOR were evaluated. Among the synthesized compounds, 4-[4-(2-methoxyphenyl)piperazin-1-yl]-N,N-dimethyl-2,2-diphenylbutanamide (20Aa) showed the highest affinity to the human MOR expressed in Chinese hamster ovary (CHO)-K1 cells, and the highest agonist potency on the MOR in isolated guinea-pig ileum preparation.