10330-42-4

Upstream product

• 21524-36-7 2,4,6-triisopropylaniline 
• 21524-34-5 2,4,6-triisopropyl-1-bromobenzene 
• 154549-38-9 2,4,6-triisopropylphenylboronic acid 

Downstream Products

• 10330-44-6 2-Chloro-4-fluoro-1,3,5-triisopropyl-benzene 
• 10330-45-7 2-Bromo-4-fluoro-1,3,5-triisopropyl-benzene 
• 10330-46-8 2-Fluoro-4-iodo-1,3,5-triisopropyl-benzene 
• 10512-67-1 2-Fluoro-1,3,5-triisopropyl-4-methyl-benzene 

Relevant academic research and scientific papers

IODINE(III)-MEDIATED RADIOFLUORINATION

A process for fluorination of aromatic compounds employing iodonium ylides and applicable to radiofluorination using 18F is described. Processes, intermediates, reagents and radiolabelled compounds are described.

Palladium(III)-catalyzed fluorination of arylboronic acid derivatives

A practical, palladium-catalyzed synthesis of aryl fluorides from arylboronic acid derivatives is presented. The reaction is operationally simple and amenable to multigram-scale synthesis. Evaluation of the reaction mechanism suggests a single-electron-transfer pathway, involving a Pd(III) intermediate that has been isolated and characterized.

Large-scale preparation of aromatic fluorides via electrophilic fluorination with functionalized aryl- or heteroarylmagnesium reagents

Functionalized aryl- or heteroarylmagnesium reagents, prepared from the corresponding bromides or iodides using halogen-magnesium exchange or direct magnesium insertion in the presence of lithium chloride, reacted smoothly with N-fluorobenzenesulfonimide, (PhSO2)2NF, in the mixed solvent (4:1 CH2Cl2-perfluorodecalin) to give the corresponding aromatic fluorides in moderate to good yields. Georg Thieme Verlag Stuttgart · New York.

Convenient electrophilic fluorination of functionalized aryl and heteroaryl magnesium reagents

"Chemical Equation Presented" Cive me an "F": Electrophilic fluorination of various aromatic and heteroaromatic Grignard reagents is smoothly performed with (PhSO2)2NF as fluorinating agent in a 4:1 mixture of CH2Cl2/ perfluorodecalin (see scheme). This solvent system allows minimization of most side reactions.