10330-59-3

Basic information

• Product Name: 3-methyl-1-(pyridin-2-yl)butan-2-one
• Synonyms: 2-butanone, 3-methyl-1-(2-pyridinyl)-; 3-Methyl-1-(pyridin-2-yl)butan-2-one
• CAS NO: 10330-59-3
• Molecular Formula: C₁₀H₁₃NO
• Molecular Weight: 163.2163
• Mol File: 10330-59-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 241.286°C at 760 mmHg
• Flash Point: 105.803°C
• Density: 1.004g/cm³
• Vapor Pressure: 0.036mmHg at 25°C
• Refractive Index: 1.5
• CAS DataBase Reference: 3-methyl-1-(pyridin-2-yl)butan-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-methyl-1-(pyridin-2-yl)butan-2-one(10330-59-3)
• EPA Substance Registry System: 3-methyl-1-(pyridin-2-yl)butan-2-one(10330-59-3)

Safety Data

• Hazardous Substances Data: 10330-59-3(Hazardous Substances Data)

Upstream product

• 109-06-8 α-picoline 
• 591-51-5 phenyllithium 
• 1749-29-7 2-pyridylmethyllithium 
• 97-62-1 Ethyl isobutyrate 
• 78-82-0 Isobutyronitrile 
• 79-30-1 isobutyryl chloride 
• 113778-69-1 N-methoxy-N-methyl-isobutyramide 
• 547-63-7 Methyl isobutyrate 

Downstream Products

• 59942-84-6 2-isopropyl-pyrazolo[1,5-a]pyridine 
• 82685-49-2 (E)-4-Methyl-1-(4-nitro-benzylsulfanyl)-1-phenylamino-2-pyridin-2-yl-pent-1-en-3-one 
• 82685-47-0 ((E)-4-Methyl-3-oxo-1-phenylamino-2-pyridin-2-yl-pent-1-enylsulfanyl)-acetic acid ethyl ester 
• 82685-48-1 ((E)-4-Methyl-3-oxo-1-phenylamino-2-pyridin-2-yl-pent-1-enylsulfanyl)-acetonitrile 
• 82685-46-9 (E)-4-Methyl-1-methylsulfanyl-1-phenylamino-2-pyridin-2-yl-pent-1-en-3-one 

Relevant articles and documents

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Synthesis, Structure-Activity Relationships, and Preclinical Evaluation of Heteroaromatic Amides and 1,3,4-Oxadiazole Derivatives as 5-HT4 Receptor Partial Agonists

Alzheimer's disease (AD) is a neurodegenerative disorder that has a higher prevalence and incidence in people older than 60 years. The need for improved AD therapies is unmet as the current therapies are symptomatic with modest efficacy. Partial agonists of the 5-HT4 receptor (5-HT4R) offer both symptomatic and disease-modifying treatments as they shift amyloid-precursor-protein (APP) processing from the amyloidogenic pathway to the nonamyloidogenic pathway by activating the α-secretase enzyme. In addition, they also offer symptomatic treatment by increasing levels of the neurotransmitter acetylcholine in the brain. Because of this fascinating dual mechanism of action, several chemical scaffolds having 5-HT4R pharmacophores were designed and evaluated. Most of the synthesized compounds showed potent in vitro affinities and in vivo efficacies. Upon analysis of focused structure-activity relationships, compound 4o was identified as a potent 5-HT4R partial agonist with favorable ADME properties and good in vivo efficacy. GR-125487, a selective 5-HT4R antagonist, attenuated the activity of compound 4o in the novel-object-recognition-test cognition model.

2-Pyridinyl β-ketones as new ligands for roomerature CuI-catalysed C-N coupling reactions

2-Pyridinyl β-ketones were identified as new efficient ligands for CuI-catalysed N-arylation of aliphatic amines at room temperature with great selectivity and substrate scope tolerance.