103304-55-8Relevant academic research and scientific papers
Synthesis of multisubstituted cycloalkenes through carbomagnesiation of strained cycloalkynes
Hosoya, Takamitsu,Karaki, Fumika,Minami, Yasunori,Nishiyama, Yoshitake,Sakata, Yuki,Tamura, Yuya,Yoshida, Suguru
supporting information, p. 7147 - 7150 (2020/07/21)
An efficient synthetic method of seven- and six-membered cycloalkenes through the generation of strained cycloalkynes and following carbomagnesiation is described. Further bond formations of the resulting cycloalkenylmagnesium intermediates with a wide variety of electrophiles enabled us to prepare diverse cycloalkene derivatives including benzoxepine analogs having a fully substituted alkene structure.
Copper-catalyzed carboarylation of alkynes via vinyl cations
Walkinshaw, Andrew J.,Xu, Wenshu,Suero, Marcos G.,Gaunt, Matthew J.
supporting information, p. 12532 - 12535 (2013/09/23)
Copper-catalyzed arylation of electron rich alkynes reveals stabilized trisubstituted vinyl cation equivalents that react with pendant arene nucleophiles to form all carbon tetrasubstituted alkenes. The new process streamlines the synthesis of important medicinally relevant molecules.
Synthesis and estrogen receptor binding of 6,7-dihydro-8-phenyl-9-[4-[2-(dimethylamino)ethoxy]phenyl]-5 H-benzocycloheptene, a nonisomerizable analogue of tamoxifen. X-ray crystallographic studies
McCague,Kuroda,Leclercq,Stoessel
, p. 2053 - 2059 (2007/10/02)
Syntheses of the title compound, a novel nonisomerizable antiestrogen containing a seven-membered ring, are described. In one method, 6,7-dihydro-9-(4-methoxyphenyl)-5H-benzocycloheptene was brominated at the 8-position and the bromine displaced by phenyl
