103304-55-8Relevant articles and documents
Synthesis of multisubstituted cycloalkenes through carbomagnesiation of strained cycloalkynes
Hosoya, Takamitsu,Karaki, Fumika,Minami, Yasunori,Nishiyama, Yoshitake,Sakata, Yuki,Tamura, Yuya,Yoshida, Suguru
supporting information, p. 7147 - 7150 (2020/07/21)
An efficient synthetic method of seven- and six-membered cycloalkenes through the generation of strained cycloalkynes and following carbomagnesiation is described. Further bond formations of the resulting cycloalkenylmagnesium intermediates with a wide variety of electrophiles enabled us to prepare diverse cycloalkene derivatives including benzoxepine analogs having a fully substituted alkene structure.
Synthesis and estrogen receptor binding of 6,7-dihydro-8-phenyl-9-[4-[2-(dimethylamino)ethoxy]phenyl]-5 H-benzocycloheptene, a nonisomerizable analogue of tamoxifen. X-ray crystallographic studies
McCague,Kuroda,Leclercq,Stoessel
, p. 2053 - 2059 (2007/10/02)
Syntheses of the title compound, a novel nonisomerizable antiestrogen containing a seven-membered ring, are described. In one method, 6,7-dihydro-9-(4-methoxyphenyl)-5H-benzocycloheptene was brominated at the 8-position and the bromine displaced by phenyl