103311-95-1

Basic information

• Product Name: 5-formyl-6-methyl-4-(3-nitrophenyl)-2-phenylpyrimidine
• CAS NO: 103311-95-1
• Molecular Weight: 319.32
• Mol File: 103311-95-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-formyl-6-methyl-4-(3-nitrophenyl)-2-phenylpyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-formyl-6-methyl-4-(3-nitrophenyl)-2-phenylpyrimidine(103311-95-1)
• EPA Substance Registry System: 5-formyl-6-methyl-4-(3-nitrophenyl)-2-phenylpyrimidine(103311-95-1)

Safety Data

• Hazardous Substances Data: 103311-95-1(Hazardous Substances Data)

Upstream product

• 103294-30-0 5-hydroxymethyl-6-methyl-4-(3-nitrophenyl)-2-phenylpyrimidine 

Relevant articles and documents

Studies on cerebral protective agents. III. Novel 4-arylpyrimidine derivatives with anti-anoxic and anti-lipid peroxidation activities. (3)

Novel 4-arylpyrimidine derivatives, bearing an amino moiety in the C-5 or C-6 position of the pyrimidine ring, were synthesized and tested for anti-anoxic (AA) activity in mice. Among them, 6,7-dihydro-6-[2-(dimethylamino)-ethyl]-4-(3-nitrophenyl)-2-phenyl-5H- pyrrolo[3,4-d]pyrimidine-5-one (2a, FR 75469) and 6-methyl-5-(4-methylpiperazin-1-ylmethyl)-4-(3-nitrophenyl)-2-phenylpy rimidine (4c, FR 72707) had comparable potency 10-100 mg/kg, i.p. and p.o. to that of 6-methyl-5-(4-methylpiperazin-1-ylcarbonyl)-4-(3-nitrophenyl)-2-phenyl pyrimidine (FK 360). These were also effective on anti-lipid peroxidation (ALP) assay and arachidonate-induced cerebral edema in rats. Structure-activity relationship in regard to AA activity of this series of compounds are discussed. Three-dimensional molecular electrostatic potentials (3D-MEP) around the nitrogeneous basic moiety of FK 360 and 5-acetyl-6-(2-dimethylaminoethyl)-4-(3-nitrophenyl)-2-phenylpyrimidine (5f) were compared, and both electrostatic potential maps were similar.