103312-33-0

Basic information

• Product Name: ethyl 2-phenyl-4-(4-nitrophenyl)-pyrimidine-5-carboxylate
• Synonyms: ethyl 2-phenyl-4-(4-nitrophenyl)-pyrimidine-5-carboxylate
• CAS NO: 103312-33-0
• Molecular Weight: 349.346
• Mol File: 103312-33-0.mol

Chemical Properties

• CAS DataBase Reference: ethyl 2-phenyl-4-(4-nitrophenyl)-pyrimidine-5-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-phenyl-4-(4-nitrophenyl)-pyrimidine-5-carboxylate(103312-33-0)
• EPA Substance Registry System: ethyl 2-phenyl-4-(4-nitrophenyl)-pyrimidine-5-carboxylate(103312-33-0)

Safety Data

• Hazardous Substances Data: 103312-33-0(Hazardous Substances Data)

Upstream product

• 838-57-3 ethyl 4-nitrobenzoylacetate 
• 1670-14-0 benzamidine monohydrochloride 
• 1188-33-6 N,N-dimethylformamide diethyl diacetal 
• 76345-09-0 ethyl 2-(4-nitrobenzoyl)-3-dimethylaminopropenoate 

Downstream Products

• 103312-32-9 4-(4-nitrophenyl)-2-phenyl-5-pyrimidinecarboxylic acid 

Relevant articles and documents

Solid phase synthesis of aminopropenones and aminopropenoates; efficient and versatile synthons for combinatorial synthesis of heterocycles

Simple and fast solid phase methods for the synthesis of heterocycles will be described. Two different three-step methods are presented. The first method includes esterifications of N-protected glycine derivatives to a solid support (Merrifield resin), formation of aminopropenoates and subsequent reaction with dinucleophiles. The second method includes methylamination of a Merrifield resin, formation of aminopropenones via in-situ formation of an active intermediate in a three-component reaction and finally treatment with dinucleophiles to form heterocycles. These procedures lead not only to the formation of heterocycles but also to simultaneous intramolecular cleavage of the products from the resin giving the product in pure form in the solution. In addition, the use of microwave dielectric heating enhanced the velocity of all reaction steps and was found to be a very efficient complement to the solid phase synthesis.

Studies on cerebral protective agents. II. Novel 4-arylpyrimidine derivatives with anti-anoxic and anti-lipid peroxidation activities.

In a search for new cerebral protective agents with anti-anoxic (AA) and anti-lipid peroxidation (ALP) activities, a series of 4-arylpyrimidines, bearing an amino moiety in the C-5 position of the pyrimidine nucleus, was synthesized and tested for AA and

Pyrimidine derivatives, processes for preparation thereof and composition containing the same

The invention relates to pyrimidine derivatives and their pharmaceutically acceptable salts which are useful in the treatment of cerebrovascular diseases, to processes for preparation thereof and to the composition containing the same, said pyrimidine der